Alzheimer's disease as homeostatic responses to age-related myelin breakdown
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This work delineates empirically testable mechanisms of action for genes underlying FAD and LOAD and provides "upstream" treatment targets and reframes key observations such as axonal transport disruptions, formation of axonal swellings/sphenoids and neuritic plaques, and proteinaceous deposits as by-products of homeostatic myelin repair processes.Citations
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The connectomics of brain disorders
TL;DR: This work considers how brain-network topology shapes neural responses to damage, highlighting key maladaptive processes and the resources and processes that enable adaptation, and shows how knowledge of network topology allows for predictive models of the spread and functional consequences of brain disease.
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The Cellular Phase of Alzheimer’s Disease
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Intramuscular desferrioxamine in patients with Alzheimer's disease
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White matter characterization with diffusional kurtosis imaging.
TL;DR: A physically meaningful interpretation of DKI metrics in white matter regions consisting of more or less parallel aligned fiber bundles is provided by modeling the tissue as two non-exchanging compartments, the intra-axonal space and extra-AXonal space.
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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Wei Ting Chen,Wei Ting Chen,Ashley Lu,Ashley Lu,Katleen Craessaerts,Katleen Craessaerts,Benjamin Pavie,Carlo Sala Frigerio,Carlo Sala Frigerio,Carlo Sala Frigerio,Nikky Corthout,Xiaoyan Qian,Jana Lalakova,Malte Kühnemund,Iryna Voytyuk,Iryna Voytyuk,Leen Wolfs,Leen Wolfs,Renzo Mancuso,Renzo Mancuso,Evgenia Salta,Evgenia Salta,Sriram Balusu,Sriram Balusu,An Snellinx,An Snellinx,Sebastian Munck,Aleksandra Jurek,José Fernández Navarro,Takaomi C. Saido,Inge Huitinga,Inge Huitinga,Joakim Lundeberg,Mark Fiers,Mark Fiers,Mark Fiers,Bart De Strooper,Bart De Strooper,Bart De Strooper +38 more
TL;DR: Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.
References
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Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: Implications for cognitive decline and dementia
TL;DR: In later-myelinating regions, the severity and rate of myelin breakdown in healthy older individuals are associated with APOE status and support the hypothesis that this process may contribute to age at onset of AD.
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Association Between Apolipoprotein E4 and Cognitive Decline in Elderly Adults
Chris J. Packard,Rudi G. J. Westendorp,David J. Stott,Muriel J. Caslake,Heather Murray,James Shepherd,Gerard J. Blauw,Mike Murphy,Edward L.E.M. Bollen,Brendan M. Buckley,Stuart M. Cobbe,Ian Ford,Allan Gaw,Michael E. Hyland,J. Wouter Jukema,Adriaan M. Kamper,Peter W. Macfarlane,Jellemer Jolles,Ivan J. Perry,Brian Sweeney,C. Twomey +20 more
TL;DR: In this article, a prospective study was conducted to determine the influence of apolipoprotein E (EPE) in individuals aged 70 to 82 from theProspectiveStudy of PravastatinintheElderly at Risk (PROSPER).
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Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPARγ:RXR heterodimers: comparison with other polyunsaturated fatty acids
Fernando Zapata-Gonzalez,Felix Rueda,Jordi Petriz,Pere Domingo,Francesc Villarroya,Francesc Villarroya,Julieta Díaz-Delfín,Julieta Díaz-Delfín,Maria A. de Madariaga,Joan Carles Domingo +9 more
TL;DR: The results strongly suggest that the PPARγ:RXR heterodimer is the pathway component activated by DHA to induce its immunomodulatory effect on DCs.
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Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease.
Jack T. Rogers,Ashley I. Bush,Hyan-Hee Cho,Deborah H. Smith,Andrew M. Thomson,Avi L. Friedlich,Debomoy K. Lahiri,Peter J. Leedman,Xudong Huang,Xudong Huang,Catherine M. Cahill +10 more
TL;DR: It is reported that APP was regulated at the translational level by active IL (interleukin)-1 (IL-1-responsive acute box) and IRE (iron-responsive element) RNA stem-loops in the 5' untranslated region of APP mRNA.
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Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus.
S. Favreliere,S. Stadelmann-Ingrand,F. Huguet,D. De Javel,A. Piriou,C. Tallineau,Georges Durand +6 more
TL;DR: Hippocampus and frontal cortex underwent specific age-induced modifications in PmE and PE acyl composition, which could produce different effects on the functional ability of these two structures involved in the processes of specific memorization.