Alzheimer's disease as homeostatic responses to age-related myelin breakdown
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TLDR
This work delineates empirically testable mechanisms of action for genes underlying FAD and LOAD and provides "upstream" treatment targets and reframes key observations such as axonal transport disruptions, formation of axonal swellings/sphenoids and neuritic plaques, and proteinaceous deposits as by-products of homeostatic myelin repair processes.Citations
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The connectomics of brain disorders
TL;DR: This work considers how brain-network topology shapes neural responses to damage, highlighting key maladaptive processes and the resources and processes that enable adaptation, and shows how knowledge of network topology allows for predictive models of the spread and functional consequences of brain disease.
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The Cellular Phase of Alzheimer’s Disease
TL;DR: Evidence supporting a long, complex cellular phase consisting of feedback and feedforward responses of astrocytes, microglia, and vasculature is reviewed.
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Intramuscular desferrioxamine in patients with Alzheimer's disease
TL;DR: In this paper, a single-blind study was conducted to investigate whether the progression of dementia could be slowed by the trivalent ion chelator, desferrioxamine.
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White matter characterization with diffusional kurtosis imaging.
TL;DR: A physically meaningful interpretation of DKI metrics in white matter regions consisting of more or less parallel aligned fiber bundles is provided by modeling the tissue as two non-exchanging compartments, the intra-axonal space and extra-AXonal space.
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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.
Wei Ting Chen,Wei Ting Chen,Ashley Lu,Ashley Lu,Katleen Craessaerts,Katleen Craessaerts,Benjamin Pavie,Carlo Sala Frigerio,Carlo Sala Frigerio,Carlo Sala Frigerio,Nikky Corthout,Xiaoyan Qian,Jana Lalakova,Malte Kühnemund,Iryna Voytyuk,Iryna Voytyuk,Leen Wolfs,Leen Wolfs,Renzo Mancuso,Renzo Mancuso,Evgenia Salta,Evgenia Salta,Sriram Balusu,Sriram Balusu,An Snellinx,An Snellinx,Sebastian Munck,Aleksandra Jurek,José Fernández Navarro,Takaomi C. Saido,Inge Huitinga,Inge Huitinga,Joakim Lundeberg,Mark Fiers,Mark Fiers,Mark Fiers,Bart De Strooper,Bart De Strooper,Bart De Strooper +38 more
TL;DR: Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.
References
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Cortical Gray Matter Volumes Are Associated with Subjective Responses to Cocaine Infusion
George Bartzokis,Mace Beckson,Po H. Lu,Po H. Lu,Nancy Edwards,Nancy Edwards,Ruth Rapoport,Peter Bridge,Jim Mintz,Jim Mintz +9 more
TL;DR: The data suggest that frontal and temporal lobe gray matter volume is associated with some of the reinforcing effects of cocaine and may be a marker for the neurobiological substrate of the age-related reduction in addiction rates.
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Effects of docosahexaenoic acid on some megakaryocytic cell gene expression of some enzymes controlling prostanoid synthesis.
Nicolas Guillot,Cyrille Debard,Catherine Calzada,Hubert Vidal,Michel Lagarde,Evelyne Véricel +5 more
TL;DR: The effects of DHA on cellular redox status could, with others, provide an explanation for the beneficial influence of low consumption of D HA on cardiovascular events.
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Biochemical Characterization of Phospholipids, Sulfatide and Heparin as Potent Stimulators for Autophosphorylation of GSK-3β and the GSK-3β-Mediated Phosphorylation of Myelin Basic Protein In vitro
TL;DR: The results presented here suggest that these two phospholipids and SH may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK -3beta-mediated high phosphorylated proteins, including MBP and TP, in the highly accumulated levels of these acidic and sulfated modulators in the brain.
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Experimental inhibition of peroxisomal beta-oxidation in rats: influence on brain myelination.
TL;DR: Oral administration of thioridazine, an inhibitor of peroxisomal β‐oxidation, to normal rats from weaning till day 60 causes a small increase of the very long chain fatty acid C26 in brain lipids and myelination in the brain is decreased.
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No change in total length of white matter fibers in Alzheimer's disease
TL;DR: The total subcortical myelinated nerve fiber length was estimated in postmortem brains from eight females with severe Alzheimer's disease and compared with brains from 10 female control subjects using a stereological method.