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An electrochemical biosensor to simultaneously detect VEGF and PSA for early prostate cancer diagnosis based on graphene oxide/ssDNA/PLLA nanoparticles
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TLDR
A novel fabrication method for producing a dual-modality biosensor that can simultaneously detect vascular endothelial growth factor (VEGF) and prostate-specific antigen (PSA) in human serum for early diagnosis of PCa is reported.About:
This article is published in Biosensors and Bioelectronics.The article was published on 2017-03-15. It has received 179 citations till now. The article focuses on the topics: Ascorbic acid.read more
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Electrochemical sensor and biosensor platforms based on advanced nanomaterials for biological and biomedical applications.
TL;DR: This review focuses on the newest development in the design of sensing and biosensing platforms based on functional nanomaterials for biological and biomedical applications, which have fascinated the interdisciplinary research arenas spanning chemistry, material science, biological science, and medical industries.
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A review on graphene-based nanocomposites for electrochemical and fluorescent biosensors
TL;DR: Graphene and its oxygenated derivatives, including reduced graphene oxide (rGO), are becoming an important class of nanomaterials in the field of biosensors as discussed by the authors, and the discovery of graphene has spectacularly accelerated research on fabricating low-cost electrode materials because of its unique physical properties, including high specific surface area, high carrier mobility, high electrical conductivity, flexibility.
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Electrically-Transduced Chemical Sensors Based on Two-Dimensional Nanomaterials
TL;DR: Key advances in the application of 2D materials, from both a historical and analytical perspective, are summarized for four different groups of analytes: gases, volatile compounds, ions, and biomolecules.
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Graphene-Based Materials for Biosensors: A Review.
TL;DR: The points of view on the intrinsic properties of graphene and its surface engineering concerned with the transduction mechanisms in biosensing applications are presented and practical synthesis techniques along with prospective properties of the graphene-based materials are explained.
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Progress in utilisation of graphene for electrochemical biosensors.
TL;DR: This review discusses recent graphene (GR) electrochemical biosensor for accurate detection of biomolecules through effective immobilization of enzymes, including glucose oxidase, horseradish peroxidase, and haemoglobin.
References
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Journal ArticleDOI
Electric Field Effect in Atomically Thin Carbon Films
Kostya S. Novoselov,Andre K. Geim,Sergey V. Morozov,Da Jiang,Y. Zhang,S. V. Dubonos,Irina V. Grigorieva,A. A. Firsov +7 more
TL;DR: Monocrystalline graphitic films are found to be a two-dimensional semimetal with a tiny overlap between valence and conductance bands and they exhibit a strong ambipolar electric field effect.
Journal ArticleDOI
Synthesis of graphene-based nanosheets via chemical reduction of exfoliated graphite oxide
Sasha Stankovich,Dmitriy A. Dikin,Richard D. Piner,Kevin A. Kohlhaas,Alfred Kleinhammes,Yuanyuan Jia,Yue Wu,SonBinh T. Nguyen,Rodney S. Ruoff +8 more
TL;DR: In this paper, a colloidal suspension of exfoliated graphene oxide sheets in water with hydrazine hydrate results in their aggregation and subsequent formation of a high surface area carbon material which consists of thin graphene-based sheets.
Journal ArticleDOI
Graphene-based composite materials
Sasha Stankovich,Dmitriy A. Dikin,Geoffrey Dommett,K. Kohlhaas,Eric Zimney,Eric A. Stach,Richard D. Piner,SonBinh T. Nguyen,Rodney S. Ruoff +8 more
TL;DR: The bottom-up chemical approach of tuning the graphene sheet properties provides a path to a broad new class of graphene-based materials and their use in a variety of applications.
Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Journal ArticleDOI
Screening and Prostate-Cancer Mortality in a Randomized European Study
Fritz H. Schröder,Jonas Hugosson,Monique J. Roobol,Stefano Ciatto,Vera Nelen,Maciej Kwiatkowski,Marcos Lujan,Hans Lilja,Marco Zappa,Louis Denis,Franz Recker,A. Berenguer,Liisa Määttänen,Chris H. Bangma,Gunnar Aus,Arnauld Villers,Xavier Rebillard,Theodorus van der Kwast,Bert G. Blijenberg,Sue Moss,Harry J. de Koning,Anssi Auvinen +21 more
TL;DR: PSA-based screening reduced the rate of death from prostate cancer by 20% but was associated with a high risk of overdiagnosis.