Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar
Vesna Jevtovic-Todorovic,Anthony Absalom,Klas Blomgren,Ansgar M. Brambrink,G. Crosby,Deborah J. Culley,Gary Fiskum,Rona G. Giffard,Karl F. Herold,Andreas W. Loepke,Daqing Ma,Beverley A. Orser,Emmanuel Planel,W. Slikker,Sulpicio G. Soriano,G. Stratmann,Laszlo Vutskits,Zhongcong Xie,Hugh C. Hemmings +18 more
TLDR
mounting evidence from preclinical studies reveals general anaesthetics to be powerful modulators of neuronal development and function, which could contribute to detrimental behavioural outcomes, however, definitive clinical data remain elusive.Abstract:
Although previously considered entirely reversible, general anaesthesia is now being viewed as a potentially significant risk to cognitive performance at both extremes of age. A large body of preclinical as well as some retrospective clinical evidence suggest that exposure to general anaesthesia could be detrimental to cognitive development in young subjects, and might also contribute to accelerated cognitive decline in the elderly. A group of experts in anaesthetic neuropharmacology and neurotoxicity convened in Salzburg, Austria for the BJA Salzburg Seminar on Anaesthetic Neurotoxicity and Neuroplasticity. This focused workshop was sponsored by the British Journal of Anaesthesia to review and critically assess currently available evidence from animal and human studies, and to consider the direction of future research. It was concluded that mounting evidence from preclinical studies reveals general anaesthetics to be powerful modulators of neuronal development and function, which could contribute to detrimental behavioural outcomes. However, definitive clinical data remain elusive. Since general anaesthesia often cannot be avoided regardless of patient age, it is important to understand the complex mechanisms and effects involved in anaesthesia-induced neurotoxicity, and to develop strategies for avoiding or limiting potential brain injury through evidence-based approaches.read more
Citations
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Journal ArticleDOI
Postoperative Delirium and Cognitive Dysfunction after General and Regional Anesthesia: A Systematic Review and Meta-Analysis
Dmitriy Viderman,Fatima Nabidollayeva,Mina Aubakirova,Dinara Yessimova,Rafael Badenes,Yerkin G. Abdildin +5 more
TL;DR: In this paper , the authors compared the effect of general anesthesia (GA) and regional anesthesia (RA) in patients undergoing surgical procedures under general anesthesia and regional anaesthetic, and found that there was no statistically significant difference between GA and RA in the incidence of post-operative cognitive dysfunction.
Posted ContentDOI
Resting state functional connectivity in early post-anesthesia recovery is characterized by globally reduced anticorrelations
Tommer Nir,Yael Jacob,Kuang-Han Huang,Arthur E. Schwartz,Jess W. Brallier,Helen Ahn,Prantik Kundu,Cheuk Y. Tang,Bradley N. Delman,Patrick J. McCormick,Mary Sano,Stacie Deiner,Mark G. Baxter,Joshua S. Mincer +13 more
TL;DR: Normal peri-anesthetic changes in resting state connectivity in healthy older adults are defined, with individual regions-of-interest essentially returning to their pre-anesthesia connectivity levels.
Book ChapterDOI
Neurotoxicity of General Anesthetics
TL;DR: It is observed that otherwise healthy children who underwent short general anesthetics in conjunction with limited surgery at very young age had no cognitive impairments later in life, and the implication of this information on anesthetic practice in pediatric patients remains to be seen.
Posted ContentDOI
A novel synthetic peptide provides neuroprotection and rescues rat cortical neurons from anesthetic-induced cell death and modulation of growth and synaptic assembly
Fahad Iqbal,Marcus Pehar,Andrew J. Thompson,Urva Azeem,Kiana Jahanbakhsh,Nerea Jimenez-Tellez,Rasha Sabouny,Shadab Batool,Atika Ibrahim,Jennifer Chow,P.V.S. Machiraju,Timothy E. Shutt,Kamrab Yusuf,Jane Shearer,Tiffany Rice,Naweed I. Syed +15 more
TL;DR: In this paper, a comparative analysis of three key general anesthetics (desflurane, propofol, and ketamine) under identical conditions and demonstrating their impact on cellular viability, neurite outgrowth, and synaptic network assembly on neonatal rat cortical neurons was provided.
Posted ContentDOI
A common human brain-derived neurotrophic factor polymorphism leads to sustained depression of excitatory synaptic transmission by isoflurane in hippocampus
TL;DR: It is shown that brain-derived neurotrophic factor (BDNF), a growth factor implicated in synaptic plasticity and dysfunction, enhances glutamate synaptic vesicle exocytosis, and that attenuation of vesicular BDNF release by isoflurane contributes to transient depression of excitatory synaptic transmission in mice.
References
More filters
Journal ArticleDOI
The classical complement cascade mediates CNS synapse elimination.
Beth Stevens,Nicola J. Allen,Luis E. Vazquez,Gareth R. Howell,Karen S. Christopherson,Navid Nouri,Kristina D. Micheva,Adrienne K. Mehalow,Andrew D. Huberman,Benjamin K. Stafford,Alexander Sher,Alan Litke,John D. Lambris,Stephen J. Smith,Simon W. M. John,Ben A. Barres +15 more
TL;DR: It is shown that C1q, the initiating protein in the classical complement cascade, is expressed by postnatal neurons in response to immature astrocytes and is localized to synapses throughout the postnatal CNS and retina, supporting a model in which unwanted synapses are tagged by complement for elimination and suggesting that complement-mediated synapse elimination may become aberrantly reactivated in neurodegenerative disease.
Journal ArticleDOI
Comparative aspects of the brain growth spurt
John Dobbing,Jean Sands +1 more
TL;DR: The brain in all species appears to grow through a sigmoid trajectory when its weight is plotted against its age, but the timing of the brain growth spurt is different in relation to birth in different species, so this must be one of the major factors to be taken into account when any attempt is made to extrapolate results obtained in one species to any other.
Journal ArticleDOI
Excitatory actions of gaba during development: the nature of the nurture.
TL;DR: This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.
Journal ArticleDOI
Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study
J. T. Moller,Pjm Pierre Cluitmans,Lars S. Rasmussen,Peter J. Houx,H Rasmussen,Jaume Canet,Patrick Rabbitt,Jellemer Jolles,K. Larsen,CD Hanning,Olivier Langeron,T Johnson,PM Lauven,P A Kristensen,A Biedler,H van Beem,O Fraidakis,Jeffrey H. Silverstein,Jew Jan Beneken,JS Gravenstein +19 more
TL;DR: The findings of this international multicentre study have implications for studies of the causes of cognitive decline and, in clinical practice, for the information given to patients before surgery.
Journal ArticleDOI
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
Erik D. Roberson,Kimberly Scearce-Levie,Jorge J. Palop,Fengrong Yan,Irene H. Cheng,Tiffany Wu,Hilary Gerstein,Gui Qiu Yu,Lennart Mucke +8 more
TL;DR: Reducing endogenous tau levels prevented behavioral deficits in transgenic mice expressing human amyloid precursor protein, without altering their high Aβ levels, and protected both transgenic and nontransgenic mice against excitotoxicity.
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