Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar
Vesna Jevtovic-Todorovic,Anthony Absalom,Klas Blomgren,Ansgar M. Brambrink,G. Crosby,Deborah J. Culley,Gary Fiskum,Rona G. Giffard,Karl F. Herold,Andreas W. Loepke,Daqing Ma,Beverley A. Orser,Emmanuel Planel,W. Slikker,Sulpicio G. Soriano,G. Stratmann,Laszlo Vutskits,Zhongcong Xie,Hugh C. Hemmings +18 more
TLDR
mounting evidence from preclinical studies reveals general anaesthetics to be powerful modulators of neuronal development and function, which could contribute to detrimental behavioural outcomes, however, definitive clinical data remain elusive.Abstract:
Although previously considered entirely reversible, general anaesthesia is now being viewed as a potentially significant risk to cognitive performance at both extremes of age. A large body of preclinical as well as some retrospective clinical evidence suggest that exposure to general anaesthesia could be detrimental to cognitive development in young subjects, and might also contribute to accelerated cognitive decline in the elderly. A group of experts in anaesthetic neuropharmacology and neurotoxicity convened in Salzburg, Austria for the BJA Salzburg Seminar on Anaesthetic Neurotoxicity and Neuroplasticity. This focused workshop was sponsored by the British Journal of Anaesthesia to review and critically assess currently available evidence from animal and human studies, and to consider the direction of future research. It was concluded that mounting evidence from preclinical studies reveals general anaesthetics to be powerful modulators of neuronal development and function, which could contribute to detrimental behavioural outcomes. However, definitive clinical data remain elusive. Since general anaesthesia often cannot be avoided regardless of patient age, it is important to understand the complex mechanisms and effects involved in anaesthesia-induced neurotoxicity, and to develop strategies for avoiding or limiting potential brain injury through evidence-based approaches.read more
Citations
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SIAARTI-SARNePI Clinical-Organizational Standards for pediatric anesthesia.
Nicola Disma,Edoardo Calderini +1 more
TL;DR: This document sets out the clinical standards aimed at limiting the risk of major complications during general or regional anaesthesia, or deep sedation, in children.
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Effects of sevoflurane and clonidine on acid base status and long-term emotional and cognitive outcomes in spontaneously breathing rat pups
Nicole Almenrader,Nicole Almenrader,Paola Colucci,Valentina De Castro,Daniela Valeri,Maura Palmery,Viviana Trezza,Patrizia Campolongo +7 more
TL;DR: Sixty minutes of sevoflurane anaesthesia in newborn rats, either alone or combined with clonidine, caused severe hypercapnic acidosis in spontaneously breathing rat pups, but was devoid of long-term behavioural dysfunctions in the present setting.
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Anestesia y paciente anciano, en busca de mejores desenlaces neurológicos
TL;DR: Las instituciones y personal a cargo del paciente anciano deben contar con la preparacion y conocimiento necesarios para el manejo of this grupo de pacientes, with el fin of mantener the independencia and salud fisica and mental tan importantes in the etapa final of the vida.
Journal ArticleDOI
A synthetic peptide rescues rat cortical neurons from anesthetic-induced cell death, perturbation of growth and synaptic assembly
Fahad Iqbal,Marcus Pehar,Andrew J. Thompson,Urva Azeem,Kiana Jahanbakhsh,Nerea Jimenez-Tellez,Rasha Sabouny,Shadab Batool,Atika Syeda,Jennifer Chow,P.V.S. Machiraju,Timothy E. Shutt,Kamran Yusuf,Jane Shearer,Tiffany Rice,Naweed I. Syed +15 more
TL;DR: In this paper, a comparative analysis of three key anesthetics (desflurane, propofol, and ketamine) when used under identical conditions, and demonstrates their impact on neonatal, rat cortical neuronal viability, neurite outgrowth and synaptic assembly.
Journal ArticleDOI
Transient changes in white matter microstructure during general anesthesia.
Cheuk Y. Tang,Victoria X. Wang,Min Yin Lun,Joshua S. Mincer,Johnny Ng,Jess W. Brallier,Arthur E. Schwartz,Helen Ahn,Patrick J. McCormick,Tommer Nir,Bradley N. Delman,Mary Sano,Stacie Deiner,Mark G. Baxter +13 more
TL;DR: In this paper, the white matter microstructure of healthy control subjects under sevoflurane anesthesia with their awake state was compared using diffusion tensor imaging (DTI) metrics.
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