Angiotensin II for the Treatment of Vasodilatory Shock.
Ashish Khanna,Shane W. English,Xueyuan S. Wang,Kealy R. Ham,James A. Tumlin,Harold M. Szerlip,Laurence W. Busse,Laith Altaweel,Timothy E Albertson,Caleb Mackey,Michael T. McCurdy,David W. Boldt,Stefan N. Chock,Paul J Young,Kenneth Krell,Richard G. Wunderink,Marlies Ostermann,Raghavan Murugan,Michelle N. Gong,Rakshit Panwar,Johanna Hästbacka,Raphael Favory,Balasubramanian Venkatesh,B. Taylor Thompson,Rinaldo Bellomo,Jeffrey B. Jensen,Jeffrey B. Jensen,Stew Kroll,Lakhmir S. Chawla,George F. Tidmarsh,George F. Tidmarsh,George F. Tidmarsh,Adam M. Deane +32 more
TLDR
Angiotensin II effectively increased blood pressure in patients with vasodilatory shock that did not respond to high doses of conventional vasopressors.Abstract:
BackgroundVasodilatory shock that does not respond to high-dose vasopressors is associated with high mortality. We investigated the effectiveness of angiotensin II for the treatment of patients with this condition. MethodsWe randomly assigned patients with vasodilatory shock who were receiving more than 0.2 μg of norepinephrine per kilogram of body weight per minute or the equivalent dose of another vasopressor to receive infusions of either angiotensin II or placebo. The primary end point was a response with respect to mean arterial pressure at hour 3 after the start of infusion, with response defined as an increase from baseline of at least 10 mm Hg or an increase to at least 75 mm Hg, without an increase in the dose of background vasopressors. ResultsA total of 344 patients were assigned to one of the two regimens; 321 received a study intervention (163 received angiotensin II, and 158 received placebo) and were included in the analysis. The primary end point was reached by more patients in the angiote...read more
Citations
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Trends in GPCR drug discovery: new agents, targets and indications
Alexander S. Hauser,Misty M. Attwood,Mathias Rask-Andersen,Helgi B. Schiöth,David E. Gloriam +4 more
TL;DR: An up-to-date analysis of all GPCR drugs and agents in clinical trials is reported, which reveals current trends across molecule types, drug targets and therapeutic indications, including showing that 475 drugs act at 108 unique GPCRs.
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Sepsis and septic shock
TL;DR: Improved basic care driven by education and quality-improvement programmes offers the best hope of increasing favourable outcomes in sepsis.
Journal ArticleDOI
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.
Laura Evans,Andrew Rhodes,Waleed Alhazzani,Massimo Antonelli,Craig M. Coopersmith,Craig French,Flávia Ribeiro Machado,Lauralyn McIntyre,Marlies Ostermann,Hallie C. Prescott,Christa Schorr,Steven Q. Simpson,W. Joost Wiersinga,Fayez Alshamsi,Derek C. Angus,Yaseen M. Arabi,Luciano Cesar Pontes Azevedo,Richard Beale,Gregory J. Beilman,Emilie P. Belley-Côté,Lisa Burry,Maurizio Cecconi,John Centofanti,Angel Coz Yataco,Jan De Waele,R. Phillip Dellinger,Kent Doi,Bin Du,Elisa Estenssoro,Ricard Ferrer,Charles D. Gomersall,Carol L. Hodgson,Morten Hylander Møller,Theodore J. Iwashyna,Shevin T. Jacob,Ruth M. Kleinpell,Michael Klompas,Michael Klompas,Younsuck Koh,Anand Kumar,Arthur Kwizera,Suzana Margareth Lobo,Henry Masur,Steven McGloughlin,Sangeeta Mehta,Yatin Mehta,Mervyn Mer,Mark E. Nunnally,Simon Oczkowski,Tiffany M. Osborn,Elizabeth Papathanassoglou,Anders Perner,Michael A. Puskarich,Jason A. Roberts,William D. Schweickert,Maureen A. Seckel,Jonathan E. Sevransky,Charles L. Sprung,Charles L. Sprung,Tobias Welte,Janice L. Zimmerman,Mitchell M. Levy +61 more
TL;DR: The Surviving Sepsis Campaign (SSC) guidelines provide evidence-based recommendations on the recognition and management of sepsis and its complications as discussed by the authors, which are either strong or weak, or in the form of best practice statements.
Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Laura Evans,Andrew Rhodes,Waleed Alhazzani,Massimo Antonelli,Craig M. Coopersmith,Craig French,Flávia Ribeiro Machado,Lauralyn McIntyre,Marlies Ostermann,Hallie C. Prescott,Christa Schorr,Steven Q. Simpson,W. Joost Wiersinga,Fayez Alshamsi,Derek C. Angus,Yaseen M. Arabi,Luciano Cesar Pontes Azevedo,Richard Beale,Gregory J. Beilman,Emilie P. Belley-Côté,Lisa Burry,Maurizio Cecconi,John Centofanti,Angel Coz Yataco,Jan De Waele,R. Phillip Dellinger,Kent Doi,Bin Du,Elisa Estenssoro,Ricard Ferrer,Charles D. Gomersall,Carol L. Hodgson,Morten Hylander Møller,Theodore J. Iwashyna,Shevin T. Jacob,Ruth M. Kleinpell,Michael Klompas,Younsuck Koh,Anand Kumar,Arthur Kwizera,Suzana Margareth Lobo,Henry Masur,Steven McGloughlin,Sangeeta Mehta,Yatin Mehta,Mervyn Mer,Mark E. Nunnally,Simon Oczkowski,Tiffany M. Osborn,Elizabeth Papathanassoglou,Anders Perner,Michael A. Puskarich,Jason A. Roberts,William D. Schweickert,Maureen A. Seckel,Jonathan E. Sevransky,Charles L. Sprung,Tobias Welte,Janice L. Zimmerman,Mitchell M. Levy +59 more
TL;DR: The Surviving Sepsis Campaign (SSC) guidelines provide evidence-based recommendations on the recognition and management of sepsis and its complications as mentioned in this paper, which are either strong or weak, or in the form of best practice statements.
Journal ArticleDOI
COVID-19, ACE2, and the cardiovascular consequences.
TL;DR: The current perspective critically examines the evidence for ACE2 regulation by RAAS blockade and statins, the cardiovascular benefits of ACE2, and whether ACE2 blockade is a viable approach to attenuate COVID-19.
References
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Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.
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The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.
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Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
R. Phillip Dellinger,Mitchell M. Levy,Andrew Rhodes,Djillali Annane,Herwig Gerlach,Steven M. Opal,Jonathan E. Sevransky,Charles L. Sprung,Ivor S. Douglas,Roman Jaeschke,Tiffany M. Osborn,Mark E. Nunnally,Sean R. Townsend,Konrad Reinhart,Ruth M. Kleinpell,Derek C. Angus,Clifford S. Deutschman,Flávia Ribeiro Machado,Gordon D. Rubenfeld,Steven A R Webb,Richard Beale,Jean Louis Vincent,Rui Moreno +22 more
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Journal ArticleDOI
APACHE II--a severity of disease classification system.
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