Animal models of fibrotic lung disease.
Bethany B. Moore,William Lawson,William Lawson,Tim D. Oury,Thomas H. Sisson,Krishnan Raghavendran,Cory M. Hogaboam +6 more
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Each of the models reviewed in this report offers a powerful tool for studying some aspect of fibrotic lung disease and has a much better understanding of the fact that the aged lung has increased susceptibility to fibrosis.Abstract:
Interstitial lung fibrosis can develop as a consequence of occupational or medical exposure, as a result of genetic defects, and after trauma or acute lung injury leading to fibroproliferative acute respiratory distress syndrome, or it can develop in an idiopathic manner. The pathogenesis of each form of lung fibrosis remains poorly understood. They each result in a progressive loss of lung function with increasing dyspnea, and most forms ultimately result in mortality. To better understand the pathogenesis of lung fibrotic disorders, multiple animal models have been developed. This review summarizes the common and emerging models of lung fibrosis to highlight their usefulness in understanding the cell–cell and soluble mediator interactions that drive fibrotic responses. Recent advances have allowed for the development of models to study targeted injuries of Type II alveolar epithelial cells, fibroblastic autonomous effects, and targeted genetic defects. Repetitive dosing in some models has more closely mimicked the pathology of human fibrotic lung disease. We also have a much better understanding of the fact that the aged lung has increased susceptibility to fibrosis. Each of the models reviewed in this report offers a powerful tool for studying some aspect of fibrotic lung disease.read more
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Book ChapterDOI
Animal and Human Models of Tissue Repair and Fibrosis: An Introduction.
David Lagares,Boris Hinz +1 more
TL;DR: In this article, the authors summarize the most widely used mouse models used to study myofibroblasts in tissue repair and fibrosis as well as genetic tools for manipulating myofibrroblast repair functions in vivo.
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A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents
Rohan S. Virgincar,Jerry Dahlke,Scott H. Robertson,Nathann Morand,Yi Qi,Simone Degan,Bastiaan Driehuys,John Nouls +7 more
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Pulmonary Fibrosis as a Result of Acute Lung Inflammation: Molecular Mechanisms, Relevant In Vivo Models, Prognostic and Therapeutic Approaches
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The self-fulfilling prophecy of pulmonary fibrosis: a selective inspection of pathological signalling loops.
A.R. Rackow,David J. Nagel,Claire E. McCarthy,Jennifer L. Judge,Shannon Lacy,Margaret A.T. Freeberg,Thomas H. Thatcher,R. Matthew Kottmann,Patricia J. Sime,Patricia J. Sime +9 more
TL;DR: In this paper, a review of specific feed forward loops demonstrated to play a role in the pathogenesis of pulmonary fibrosis is presented, focusing on the overlapping signaling mediators among the many pro-fibrotic pathways and how the loss of pro-resolving mediators may contribute to the propagation of disease.
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What can an organ-on-a-chip teach us about human lung physiology?
Haiqing Bai,Donald E. Ingber +1 more
TL;DR: How an organ-on-a-chip (organ chip) is a bioengineered microfluidic cell culture device lined by living cells and tissues that recapitulates organ-level functions in vitro is discussed.
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Mary Armanios,Julian J.-L. Chen,Joy D. Cogan,Jonathan K. Alder,Roxann G. Ingersoll,Cheryl Markin,William Lawson,William Lawson,Mingyi Xie,Irma Vulto,John A. Phillips,Peter M. Lansdorp,Carol W. Greider,James E. Loyd +13 more
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