Animal models of fibrotic lung disease.
Bethany B. Moore,William Lawson,William Lawson,Tim D. Oury,Thomas H. Sisson,Krishnan Raghavendran,Cory M. Hogaboam +6 more
TLDR
Each of the models reviewed in this report offers a powerful tool for studying some aspect of fibrotic lung disease and has a much better understanding of the fact that the aged lung has increased susceptibility to fibrosis.Abstract:
Interstitial lung fibrosis can develop as a consequence of occupational or medical exposure, as a result of genetic defects, and after trauma or acute lung injury leading to fibroproliferative acute respiratory distress syndrome, or it can develop in an idiopathic manner. The pathogenesis of each form of lung fibrosis remains poorly understood. They each result in a progressive loss of lung function with increasing dyspnea, and most forms ultimately result in mortality. To better understand the pathogenesis of lung fibrotic disorders, multiple animal models have been developed. This review summarizes the common and emerging models of lung fibrosis to highlight their usefulness in understanding the cell–cell and soluble mediator interactions that drive fibrotic responses. Recent advances have allowed for the development of models to study targeted injuries of Type II alveolar epithelial cells, fibroblastic autonomous effects, and targeted genetic defects. Repetitive dosing in some models has more closely mimicked the pathology of human fibrotic lung disease. We also have a much better understanding of the fact that the aged lung has increased susceptibility to fibrosis. Each of the models reviewed in this report offers a powerful tool for studying some aspect of fibrotic lung disease.read more
Citations
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Andrographolide alleviates bleomycin-induced NLRP3 inflammasome activation and epithelial-mesenchymal transition in lung epithelial cells by suppressing AKT/mTOR signaling pathway
Jingpei Li,Xiaohan Yang,Penghui Yang,Ke Xu,Xiaomin Peng,Weipeng Cai,Simin Zhao,Lei Hu,Zhuoyi Li,Fei Cui,Wei Wang,Guilin Peng,Xin Xu,Jianxing He,Jun Liu +14 more
TL;DR: In this paper, Andrographolide (Andro) was used to attenuate bleomycin-induced NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and epithelial-mesenchymal transition (EMT).
Journal ArticleDOI
Occupational Contributions to Interstitial Lung Disease.
TL;DR: Historically well-recognized occupational threats such as coal workers pneumoconiosis, silicosis, and asbestosis remain important and are very likely underestimated in measures of global disease burden.
Journal ArticleDOI
Oral administration of curcumin ameliorates pulmonary fibrosis in mice through 15d-PGJ2-mediated induction of hepatocyte growth factor in the colon.
TL;DR: It was shown that oral administration of curcumin indeed significantly increased the expression of gut-derived hepatocyte growth factor (HGF) in colon tissues, and in bleomycin- and SiO 2 -treated mice, the upregulated protein level of HGF in lungs by oralCurcumin was highly correlated with its anti-PF effect.
Journal ArticleDOI
A Novel Fibroblast Reporter Cell Line for in vitro Studies of Pulmonary Fibrosis.
TL;DR: The generation of a representative fibroblast reporter cell line (10-4ABFP) is reported to study pathophysiological mechanisms of IPF in high throughput or high resolution in vitro live cell assays to gain new insights into the cellular and molecular processes involved in fibrosis formation and propagation.
Journal ArticleDOI
From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science."
Marko Nikolic,Eva M. Garrido-Martin,Flavia R. Greiffo,Aurelie Fabre,Irene H. Heijink,Agnes W. Boots,Catherine M. Greene,Pieter S. Hiemstra,Sabine Bartel +8 more
TL;DR: New insights into the pathophysiology of the human alveolus, novel tools in organoid development and (epi)genome editing, as well as insights from the presented abstracts on novel therapeutic targets being identified for idiopathic pulmonary fibrosis are discussed.
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Mary Armanios,Julian J.-L. Chen,Joy D. Cogan,Jonathan K. Alder,Roxann G. Ingersoll,Cheryl Markin,William Lawson,William Lawson,Mingyi Xie,Irma Vulto,John A. Phillips,Peter M. Lansdorp,Carol W. Greider,James E. Loyd +13 more
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