Open AccessJournal Article
Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosus.
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TLDR
A new function of DNA-anti-DNA Ab complexes, IFN-alpha induction, that might be important in the pathogenesis of SLE is identified.Abstract:
Anti-double-stranded DNA antibodies and immunostimulatory plasmid DNA in combination mimic the endogenous IFN-alpha inducer in systemic lupus erythematosusread more
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CpG Motifs in Bacterial DNA and Their Immune Effects
TL;DR: Oligodeoxynucleotides containing CpG ODN enhance the development of acquired immune responses for prophylactic and therapeutic vaccination and protect against lethal challenge with a wide variety of pathogens.
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Plasmacytoid dendritic cells in immunity.
TL;DR: Recent progress on the characterization of plasmacytoid dendritic cell origin, development, migration and function in immunity and tolerance, as well as their effect on human diseases are reviewed.
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IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors.
TL;DR: After more than two decades of effort by researchers, IPCs finally claim their place in the hematopoietic chart as the most important cell type in antiviral innate immunity.
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Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Jane Tian,Ana M. Avalos,Su-Yau Mao,Bo Chen,Kannaki Senthil,Herren Wu,Peggy Parroche,Stacey Drabic,Douglas T. Golenbock,Cherilyn M. Sirois,Jing Hua,Ling-Ling An,Laurent P. Audoly,Greg La Rosa,Angelika Bierhaus,Peter Naworth,Ann Marshak-Rothstein,Mary K. Crow,Katherine A. Fitzgerald,Eicke Latz,Peter A. Kiener,Anthony J. Coyle +21 more
TL;DR: HMGB1, a nuclear DNA-binding protein released from necrotic cells, was an essential component of DNA-containing immune complexes that stimulated cytokine production through a TLR9–MyD88 pathway involving the multivalent receptor RAGE.
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Plasmacytoid predendritic cells initiate psoriasis through interferon-α production
Frank O. Nestle,Curdin Conrad,Adrian Tun-Kyi,Bernhard Homey,Michael Gombert,Onur Boyman,Günter Burg,Yong-Jun Liu,Michel Gilliet +8 more
TL;DR: It is suggested that PDCs and PDC-derived IFN-α represent potential early targets for the treatment of psoriasis and a novel innate immune pathway for triggering a common human autoimmune disease is uncovered.
References
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Journal ArticleDOI
The 1982 revised criteria for the classification of systemic lupus erythematosus
Eng M. Tan,Alan S. Cohen,James F. Fries,Alfonse T. Masi,Dennis J. McShane,Naomi F. Rothfield,Jane G. Schaller,Norman Talal,Robert Winchester +8 more
TL;DR: The 1971 preliminary criteria for the classification of systemic lupus erythematosus (SLE) were revised and updated to incorporate new immunologic knowledge and improve disease classification and showed gains in sensitivity and specificity.
Journal ArticleDOI
Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE.
TL;DR: The development of the SLEDAI is described, a validated model of experienced clinicians' global assessments of disease activity in lupus, which represents the consensus of a group of experts in the field of l upus research.
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Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
TL;DR: The results indicate that IL-10 has important regulatory effects on immunological and inflammatory responses because of its capacity to downregulate class II MHC expression and to inhibit the production of proinflammatory cytokines by monocytes.
Journal ArticleDOI
Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization
Yukio Sato,Mark Roman,H Tighe,Delphine J. Lee,Maripat Corr,Minh-Duc Nguyen,Gregg J. Silverman,Martin Lotz,Dennis A. Carson,Eyal Raz +9 more
TL;DR: Although ISS are necessary for gene vaccination, they down-regulate gene expression and thus may interfere with gene replacement therapy by inducing proinflammatory cytokines.
Journal ArticleDOI
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
Mark Roman,Elena Martín-Orozco,Justin S. Goodman,Minh-Duc Nguyen,Yukio Sato,Arash Ronaghy,Richard S. Kornbluth,Douglas D. Richman,Dennis A. Carson,Eyal Raz +9 more
TL;DR: Noncoding, ISS-enriched plasmid DMAs or ISS oligonucleotides (ISS-ODNs) potently stimulate immune responses to coadministered antigens and should be given to adding noncoding DNA adjuvants to inactivated or subunit viral vaccines that, by themselves, provide only partial protection from infection.