Journal ArticleDOI
Antitumour actions of interferons: implications for cancer therapy
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TLDR
Understanding this reciprocal interaction of IFNs will enable the development of improved single-agent or combination therapies that exploit IFN pathways and new 'omics'-based biomarkers to indicate responsive patients.Abstract:
The interferons (IFNs) are a family of cytokines that protect against disease by direct effects on target cells and by activating immune responses. The production and actions of IFNs are finely tuned to achieve maximal protection and avoid the potential toxicity associated with excessive responses. IFNs are back in the spotlight owing to mounting evidence that is reshaping how we can exploit this pathway therapeutically. As IFNs can be produced by, and act on, both tumour cells and immune cells, understanding this reciprocal interaction will enable the development of improved single-agent or combination therapies that exploit IFN pathways and new 'omics'-based biomarkers to indicate responsive patients.read more
Citations
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Dendritic cells in cancer immunology and immunotherapy.
Stefanie K. Wculek,Francisco J. Cueto,Adriana M. Mujal,Ignacio Melero,Matthew F. Krummel,David Sancho +5 more
TL;DR: How different DC subsets influence immunity and tolerance in cancer settings is outlined and the implications for both established cancer treatments and novel immunotherapy strategies are discussed.
Journal ArticleDOI
A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing
Deng Pan,Aya Kobayashi,Aya Kobayashi,Peng Jiang,Lucas Ferrari de Andrade,Rong En Tay,Adrienne M. Luoma,Daphne Tsoucas,Xintao Qiu,Klothilda Lim,Prakash Rao,Henry W. Long,Guo-Cheng Yuan,John G. Doench,Myles Brown,X. Shirley Liu,Kai W. Wucherpfennig +16 more
TL;DR: A genome-scale CRISPR-Cas9 screen was used to identify mechanisms of tumor cell resistance to killing by cytotoxic T cells, the central effectors of antitumor immunity.
Journal ArticleDOI
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy.
TL;DR: This Review focuses on recent advances in the understanding of the transcriptional, chromatin-based and metabolic mechanisms that underlie IFNγ-mediated polarization of macrophages to an ‘M1-like’ state, which is characterized by increased pro-inflammatory activity and macrophage resistance to tolerogenic and anti-inflammatory factors.
Journal ArticleDOI
Tumour-associated neutrophils in patients with cancer
Merav E. Shaul,Zvi G Fridlender +1 more
TL;DR: The evidence correlating the neutrophil-to-lymphocyte ratio with prognosis is described, followed by a discussion on the predictive value of TANs, which remains debatable, with conflicting data from different cancer types.
Journal ArticleDOI
LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
Wanqiang Sheng,Wanqiang Sheng,Martin W. LaFleur,Thao H. Nguyen,Sujun Chen,Sujun Chen,Ankur Chakravarthy,Ankur Chakravarthy,Jake Conway,Ying Li,Hao Chen,Hao Chen,Henry Yang,Pang-Hung Hsu,Eliezer M. Van Allen,Gordon J. Freeman,Daniel D. De Carvalho,Daniel D. De Carvalho,Housheng Hansen He,Housheng Hansen He,Arlene H. Sharpe,Arlene H. Sharpe,Yang Shi,Yang Shi +23 more
TL;DR: It is demonstrated that ablation of the histone demethylase LSD1 in cancer cells increases repetitive element expression, including endogenous retroviral elements (ERVs), and decreases expression of RNA-induced silencing complex (RISC) components.
References
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Journal ArticleDOI
Interferon-γ: an overview of signals, mechanisms and functions
TL;DR: The current understanding of IFN‐γ ligand, receptor, ignal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophages function during infection are reviewed.
Journal ArticleDOI
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TL;DR: Much of the cellular response to IFN-gamma can be described in terms of a set of integrated molecular programs underlying well-defined physiological systems, for example the induction of efficient antigen processing for MHC-mediated antigen presentation, which play clearly defined roles in pathogen resistance.
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TL;DR: It is anticipated that an increased understanding of the contributions of these recently identified pathways will advance current thinking about how interferons work.
Journal ArticleDOI
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TL;DR: The history of the cancer immunosurveillance controversy is summarized and its resolution and evolution into the three Es of cancer immunoediting--elimination, equilibrium, and escape are discussed.
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