Journal ArticleDOI
Arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.
TLDR
It is suggested that arecoline inhibits pineal–testis function in experimentally induced hypothyroid rats.Abstract:
Arecoline is known to cause endocrine dysfunction. In the current article role of arecoline on pineal-testis activity was investigated in hypothyroid rats induced by propylthiouracil (PTU). PTU treatment caused thyroid dysfunction ultrastructurally with a fall in T3 and T4 levels followed by a rise of thyroid stimulating hormone (TSH) level. Pineal activity was impaired by PTU treatment, as evident from degenerated synaptic ribbons and mitochondria of the pinealocytes with depletion of pineal and serum N-acetyl serotonin and melatonin levels. Leydig cell function was suppressed, evident from reduced smooth endoplasmic reticulum and depletion of testosterone level. Sex accessories function was impaired by showing scanty rough endoplasmic reticulum with depletion of fructose and sialic acid levels. Arecoline treatment that caused pineal dysfunction and testicular stimulation in control rats, suppressed both pineal and testis functions after PTU treatment. The findings suggest that arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.read more
Citations
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Journal ArticleDOI
DARK Classics in Chemical Neuroscience: Arecoline.
Andrey D. Volgin,Alim Bashirzade,Tamara G. Amstislavskaya,Oleg A. Yakovlev,Konstantin A. Demin,Ying-Jui Ho,Dongmei Wang,Vadim A. Shevyrin,Dongni Yan,Zhichong Tang,Jingtao Wang,Mengyao Wang,Erik T. Alpyshov,Nazar Serikuly,Edina A. Wappler-Guzzetta,Anton M. Lakstygal,Allan V. Kalueff +16 more
TL;DR: The importance of arecoline is supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine) and social and historical aspects of its use and abuse.
Dissertation
Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin
Journal ArticleDOI
Hypothyroidism: morphological and metabolic changes in the testis of adult albino rat and the amelioration by alpha-lipoic acid
Amal Al-Shahat Ibrahim,N A Mohammed,K A Eid,Mosleh M. Abomughaid,Aaser M. Abdelazim,Adel Mohamed Aboregela +5 more
TL;DR: AlA supplementation ameliorated the toxicity induced by hypothyroidism as illustrated by enhanced reproductive organ weights, testosterone, LH, and FSH levels, testicular steroidogenesis, and oxidative stress parameters.
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Identification of novel biomarkers and candidate small molecule drugs in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis of high-throughput data.
TL;DR: New insights into the underlying pathogenesis of RA and OA are suggested, which may improve the diagnosis and treatment of these intractable chronic diseases.
Journal ArticleDOI
ENHANCED p53-DEPENDENT GROWTH INHIBITION OF HUMAN GLIOBLASTOMA CELLS BY COMBINATORIAL TREATMENT OF TEMOZOLOMIDE AND NOVEL PURIFIED NATURAL CARBOHYDRATE OF PLEUROTUS FLORIDA
Priyankar Maji,Ranodeep Chatterjee,Shibani Basu,Biswa Choudhury,Urmi Chatterji,Jhuma Ganguly +5 more
TL;DR: It confirms that Fr-II synergizes with TMZ to significantly intensify its anti-proliferative properties, thereby emerging as an effective element for combinatorial treatment of glioblastoma.
References
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Journal ArticleDOI
Direct effects of propylthiouracil on testosterone secretion in rat testicular interstitial cells.
TL;DR: The results suggest that the inhibitory actions of PTU on testosterone secretion are exerted, at least in part, at the testicular level through a mechanism which is independent of thyroid status and which involves a reduction in P450scc activity and, hence, in the conversion of cholesterol to pregnenolone.
Journal ArticleDOI
Participation of the pineal gland in sexual maturation of female rainbow trout (Oncorhynchus mykiss Walbaum).
TL;DR: It was found that the lack of the pineal gland in the period directly preceding the spawning had no statistical effect on either spawning or the number of females that produced eggs.
Journal ArticleDOI
Arecoline augments cellular proliferation in the prostate gland of male Wistar rats.
TL;DR: The findings provide the first evidence that regular use of arecoline may lead to prostatic hyperplasia and hypertrophy, and eventually to disorders associated with prostate enlargement.
Journal ArticleDOI
The relation between reduced serum melatonin levels and zinc in rats with induced hypothyroidism
TL;DR: The results of the study demonstrate that PTU supplementation for 4 weeks results in a significant inhibition in both melatonin and zinc levels, which may result from the decrease in zinc levels.
Journal ArticleDOI
The effect of the antithyroid drug propylthiouracil on the alternative pathway of complement in rats.
Celma Gonçalves Duarte,Georgina L dos Santos,Ana Elisa Caleiro Seixas Azzolini,Ana Isabel de Assis Pandochi +3 more
TL;DR: The effect of propylthiouracil (PTU) on the lytic activity of complement in rat serum was investigated in vivo as mentioned in this paper, and the results showed a relatively small reduction (∼30%) in CP activity, evident only in animals treated with 50mg of PTU for three weeks.