Asthma Exacerbations: Pathogenesis, Prevention, and Treatment
Reads0
Chats0
TLDR
This work will review common inciting factors for asthma exacerbations and approaches to prevent and treat these events, particularly with human rhinovirus.About:
This article is published in The Journal of Allergy and Clinical Immunology: In Practice.The article was published on 2017-07-01 and is currently open access. It has received 234 citations till now. The article focuses on the topics: Asthma.read more
Citations
More filters
Journal ArticleDOI
Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease.
TL;DR: The molecular mechanisms behind the heterogeneity of airway inflammation in asthmatic patients are presented, which have shifted existing paradigms in the approach to asthma to tailor novel therapies.
Journal ArticleDOI
Anticholinergics in the treatment of children and adults with acute asthma: A systematic review with meta-analysis
TL;DR: This review strongly suggests that the addition of multiple doses of inhaled ipratropium bromide to beta(2) agonists is indicated as the standard treatment in children, adolescents, and adults with moderate to severe exacerbations of asthma in the emergency setting.
Journal ArticleDOI
Regional, age and respiratory-secretion-specific prevalence of respiratory viruses associated with asthma exacerbation: a literature review
TL;DR: The findings indicate the need to develop prophylactic polyvalent or polyvirus (including RV, EnV, IfV and RSV) vaccines that produce herd immunity and reduce the healthcare burden associated with virus-induced asthma exacerbations.
Journal ArticleDOI
IL-33/IL-31 Axis in Immune-Mediated and Allergic Diseases.
Giuseppe Murdaca,Monica Greco,Alessandro Tonacci,Simone Negrini,Matteo Borro,Francesco Puppo,Sebastiano Gangemi +6 more
TL;DR: This paper aims to give the readers a complete and updated review of IL-31 and IL-33 involvement among the most common autoimmune and allergic disorders.
Journal ArticleDOI
Spotlight on microRNAs in allergy and asthma.
Julie Weidner,Sabine Bartel,Ayşe Kılıç,Ulrich M. Zissler,Harald Renz,Jürgen Schwarze,Carsten B. Schmidt-Weber,Tania Maes,Ana Rebane,Susanne Krauss-Etschmann,Madeleine Rådinger +10 more
TL;DR: An overview of the current research on miRNAs in allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma is given and how individual miRNas function in the regulation of immune responses in epithelial cells and specialized immune cells in response to different environmental factors and respiratory viruses is discussed.
References
More filters
Journal ArticleDOI
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children.
Sebastian L. Johnston,Philip Pattemore,G. Sanderson,Sandra Smith,F Lampe,Lynn Josephs,P. Symington,S. O'Toole,S. H. Myint,D. A. J. Tyrrell +9 more
TL;DR: This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.
Journal ArticleDOI
Bronchial reactivity to inhaled histamine: a method and clinical survey.
TL;DR: An easy and safe dose‐response histamine‐inhalation test is described, to measure the level of non‐specific bronchial reactivity.
Journal ArticleDOI
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial.
Ian D. Pavord,Stephanie Korn,Peter H. Howarth,Eugene R. Bleecker,Roland Buhl,Oliver N. Keene,Hector Ortega,Pascal Chanez +7 more
TL;DR: Mepolizumab is an effective and well tolerated treatment that reduces the risk of asthma exacerbations in patients with severe eosinophilic asthma.
Journal ArticleDOI
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Pranabashis Haldar,Christopher E. Brightling,Beverley Hargadon,Sunil Gupta,W Monteiro,Ana R. Sousa,Richard P. Marshall,Peter Bradding,Ruth H. Green,Andrew J. Wardlaw,Ian D. Pavord +10 more
TL;DR: The results of this study suggest that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in this patient population.
Journal ArticleDOI
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.
Ruth H. Green,Christopher E. Brightling,S McKenna,Beverley Hargadon,Debbie Parker,Peter Bradding,Andrew J. Wardlaw,Ian D. Pavord +7 more
TL;DR: A treatment strategy directed at normalisation of the induced sputum eosinophil count reduces asthma exacerbations and admissions without the need for additional anti-inflammatory treatment.
Related Papers (5)
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung,Sally E. Wenzel,Jan Brozek,Andrew Bush,Mario Castro,Peter J. Sterk,Ian M. Adcock,Eric D. Bateman,Elisabeth H. Bel,Eugene R. Bleecker,Louis-Philippe Boulet,Christopher E. Brightling,Pascal Chanez,Sven-Erik Dahlén,Ratko Djukanovic,Urs Frey,Mina Gaga,Peter G. Gibson,Qutayba Hamid,Nizar N. Jajour,Thais Mauad,Ronald L. Sorkness,W. Gerald Teague +22 more
Role of deficient type III interferon-λ production in asthma exacerbations
Marco Contoli,Simon D. Message,Vasile Laza-Stanca,Michael R. Edwards,Peter A. B. Wark,Peter A. B. Wark,Nathan W. Bartlett,Tatiana Kebadze,Patrick Mallia,Luminita A. Stanciu,Hayley L. Parker,Louise Slater,Anita Lewis-Antes,Onn Min Kon,Stephen T. Holgate,Donna E. Davies,Sergei V. Kotenko,Alberto Papi,Sebastian L. Johnston +18 more