Atypical COVID-19 dynamics in a patient with mantle cell lymphoma exposed to rituximab
Gianpaolo Marcacci,Giuseppe Fiorentino,Francesco Volzone,Umberto Falcone,Roberto Parrella,Daniela Donnarumma,Silvia D’Ovidio,Anna Annunziata,Giovanni Micallo,Giuseppe Portella,Annarosaria De Chiara,Rosaria De Filippi,Stefania Crisci,Antonio Pinto +13 more
TLDR
In this article, a patient with mantle cell lymphoma (MCL) exposed to nine doses of Rituximab shortly before infection with severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) had a prolonged asymptomatic phase, with negative molecular and antibody testing for SARS, followed by a rapidly progressive evolution to severe COVID-19.Abstract:
Patients with non-hodgkin lymphomas (NHL) represent a population of special interest during the current Coronavirus disease-19 (COVID-19) pandemics. NHLs are associated with disease- and treatment-related immunodeficiencies which may generate unusual COVID-19 dynamics and pose unique management challenges. We report the unusual clinical course of COVID-19 in a patient with mantle cell lymphoma (MCL) exposed to nine doses of Rituximab shortly before infection with severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). He had a prolonged asymptomatic phase, with negative molecular and antibody testing for SARS-CoV-2, followed by a rapidly progressive evolution to severe COVID-19. Despite detection of viral RNA overlapped with first symptoms occurrence, anti-SARS-CoV-2 antibodies displayed an asynchronous pattern, with IgG first appearing 2 days after RNA positivity and IgM never being detected throughout the entire clinical course. While disease-associated immune derangements and/or previous treatments involving anti-CD20 antibodies might have contributed to COVID-19 dynamics in our patient, data suggests that antibody testings, without concurrent molecular assessment for SARS-CoV-2, may turn inadequate for monitoring of MCL patients, and in general NHL patients heavily exposed to anti-CD20 antibodies, during the current pandemics. We suggest that repeated molecular testing of nasopharyngeal swab should be implemented in these subjects despite a negative serology and absence of symptoms of SARS-CoV-2 infection. For the same reasons, a customized strategy needs to be developed for patients exposed to anti-CD20 antibodies, based on different features and mechanism of action of available SARS-CoV-2 vaccines and novel vaccinomics developments.read more
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Safety of administration of BNT162b2 mRNA (Pfizer-BioNTech) COVID-19 vaccine in youths and young adults with a history of acute lymphoblastic leukemia and allergy to PEG-asparaginase.
Catherine Mark,Sumit Gupta,Angela Punnett,Julia Upton,Julia Orkin,Adelle Atkinson,Lindsay Clarke,Alice Heisey,Christine McGovern,Sarah Alexander +9 more
TL;DR: A process developed to support COVID vaccination in a cohort of adolescents and young adults with a history of PEG‐ASNase allergy is described.
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COVID-19 Pneumonia in Vaccinated Population: A Six Clinical and Radiological Case Series.
Barbara Brogna,Elio Bignardi,Claudia Brogna,Chiara Capasso,Giuliano Gagliardi,Alberigo Martino,Lanfranco Musto +6 more
TL;DR: In this article, the authors report different clinical cases and radiological findings of COVID-19 pneumonia in six fully vaccinated patients and conclude that caution should be preserved, and the use of masks and social distancing should be continued in all closed environments.
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Деплеция в-клеток при иммуновоспалительных ревматических заболеваниях и коронавирусная болезнь 2019 (covid-19)
Е. Л. Насонов,А. С. Авдеева +1 more
TL;DR: According to the recommendations of the Association of Rheumatologists of Russia, a more rigorous assessment of indications for induction and maintenance therapy of RTX therapy and harmonization of the timing of drug administration and vaccination is required.
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Recovery from severe persistent COVID-19 without evidence of an anti-SARS-CoV-2 antibody response in a man with mantle cell lymphoma treated with rituximab
TL;DR: In this paper , the authors treated a man with mantle cell lymphoma treated with rituximab, who developed severe COVID-19 with viral shedding that lasted for 78 days.
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Journal ArticleDOI
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