B Cells Are Critical to T-cell—Mediated Antitumor Immunity Induced by a Combined Immune-Stimulatory/Conditionally Cytotoxic Therapy for Glioblastoma
Marianela Candolfi,James F. Curtin,Kader Yagiz,Hikmat Assi,Mia Wibowo,Gabrielle E. Alzadeh,David Foulad,Akm Ghulam Muhammad,Sofia Salehi,Sofia Salehi,Naomi Keech,Naomi Keech,Mariana Puntel,Chunyan Liu,Nicholas R. Sanderson,Kurt M. Kroeger,Robert Dunn,Gislaine Martins,Pedro R. Lowenstein,Maria G. Castro +19 more
TLDR
This article showed that modifying the tumor microenvironment through intratumoral administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, i.e., HSV1-TK and the immune-stimulatory cytokine (Flt3L) leads to T-cell-dependent tumor regression in rodent models of glioblastoma.About:
This article is published in Neoplasia.The article was published on 2011-10-01 and is currently open access. It has received 83 citations till now. The article focuses on the topics: Marginal zone B-cell & Antigen-presenting cell.read more
Citations
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B lymphocytes and cancer: a love-hate relationship.
TL;DR: In some tumors B cells may impede antitumor immunity while in others they contribute to the immunological containment of cancer.
Journal ArticleDOI
Tumor infiltrating immune cells in gliomas and meningiomas
Patrícia Domingues,María González-Tablas,Álvaro Otero,Daniel Pascual,David Miranda,Laura Ruiz,Pablo Sousa,Juana Ciudad,Jesús María Gonçalves,Maria do Carmo Lopes,Alberto Orfao,María Dolores Tabernero +11 more
TL;DR: Current knowledge about tumor-infiltrating immune cells in the two most common types of CNS tumors-gliomas and meningiomas are summarized, as well as the role that such immune cells may play in the tumor microenvironment in controlling and/or promoting tumor development, growth and control.
Journal ArticleDOI
Immune Evasion Strategies of Glioblastoma.
Seyed-Mostafa Razavi,Karen E. Lee,Benjamin E. Jin,Parvir S. Aujla,Sharareh Gholamin,Gordon Li +5 more
TL;DR: The purpose of this review is to highlight the strategies by which GBM cells evade the host immune system and pave the way for developing novel immunotherapeutic approaches for treatment of GBM.
Journal ArticleDOI
Antigen-presenting intratumoral B cells affect CD4+ TIL phenotypes in non-small cell lung cancer patients
Tullia C. Bruno,Peggy Ebner,Brandon Moore,Olivia G. Squalls,Katherine A. Waugh,Evgeniy Eruslanov,Sunil Singhal,John D. Mitchell,Wilbur A. Franklin,Daniel T. Merrick,Martin D. McCarter,Brent E. Palmer,Jeffrey A. Kern,Jill E. Slansky +13 more
TL;DR: A new role is demonstrated for TIL-Bs in NSCLC tumors in their interplay with CD4+ TILs in the tumor microenvironment, establishing them as a potential therapeutic target in NSClC immunotherapy.
Journal ArticleDOI
Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites
Powell Perng,Michael Lim +1 more
TL;DR: The immune responses in the CNS are linked and complementary to immune processes in the periphery, and advances in tumor immunotherapy in peripheral sites may therefore illuminate novel approaches to brain tumor Immunotherapy, and vice versa.
References
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CD1: antigen presentation and T cell function.
Manfred Brigl,Michael B. Brenner +1 more
TL;DR: The function of CD1-restricted T cells in antimicrobial responses, antitumor immunity, and in regulating the balance between tolerance and autoimmunity is described.
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Marginal zone b cells
TL;DR: The functions of these cells in both innate and adaptive immunity are discussed, and differing viewpoints regarding the generation and function of marginal zone B cells in rodents and primates are reconciled.
Journal ArticleDOI
Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells
Miriam Shapiro-Shelef,Kuo-I Lin,Louise J. McHeyzer-Williams,Jerry Liao,Michael G. McHeyzer-Williams,Kathryn Calame +5 more
TL;DR: Mice created with a B cell-specific deletion of prdm1, the gene encoding Blimp-1, show that in response to either TD or TI antigen, serum Ig, short-lived Plasma cells, post-GC plasma cells, and plasma cells in a memory response are virtually absent, demonstrating that Blimp-1 is required for plasmacytic differentiation and Ig secretion.
Journal ArticleDOI
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent.
TL;DR: It is reported that genetic elimination of mature T and B lymphocytes in a transgenic mouse model of inflammation-associated de novo epithelial carcinogenesis, e.g., K14-HPV16 mice, limits neoplastic progression to development of epithelial hyperplasias that fail to recruit innate immune cells.
Journal ArticleDOI
Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming.
Rhys S. Allan,Jason Waithman,Sammy Bedoui,Claerwen M. Jones,Jose A Villadangos,Yifan Zhan,Andrew M. Lew,Ken Shortman,William R. Heath,Francis R. Carbone +9 more
TL;DR: After skin infection with herpes simplex virus, cytotoxic T lymphocyte activation required MHC class I-restricted presentation by nonmigratory CD8(+) DCs rather than skin-derived DCs, which supports the argument for initial transport of antigen by migratingDCs, followed by its transfer to the lymphoid-resident DCs for presentation and CTL priming.