Benefit of Early Initiation of Neuraminidase Inhibitor Treatment to Hospitalized Patients With Avian Influenza A(H7N9) Virus
Shufa Zheng,Lingling Tang,Hainv Gao,Yiyin Wang,Fei Yu,Dawei Cui,Guoliang Xie,Xianzhi Yang,Wen Zhang,Xianfei Ye,Zi-Ke Zhang,Xi Wang,Liang Yu,Yiming Zhang,Shigui Yang,Weifeng Liang,Yu Chen,Lanjuan Li +17 more
TLDR
Early NAI therapy within 2 days of illness shortened the duration of viral shedding and improved survival in patients with H7N9 viral infection.Abstract:
Background The significance of early neuraminidase inhibitor (NAI) therapy for treating influenza A(H7N9) is currently unknown. Methods The duration of viral shedding was monitored by reverse-transcription polymerase chain reaction after patients with confirmed H7N9 infection were admitted to the First Affiliated Hospital, Zhejiang University, during April 2013-April 2017. Indices such as the length of hospitalization and mortality were collected, and the correlation between the time of administration of NAI and the severity of disease was systematically analyzed. Results One hundred sixty patients with confirmed H7N9 infection were divided into 3 groups according to NAI starting time. Three of 20 (15%) patients for whom NAI was administered within 2 days died compared with 12 of 52 (23.1%) patients who received treatment within 2-5 days and 33 of 88 (37.5%) patients who were treated after 5 days (P < .05). The median durations of viral shedding from NAI therapy initiation was 4.5 days (interquartile range [IQR], 3-9 days) for patients who took antiviral medication within 2 days, which was significantly different from that for patients who took medication within 2-5 days (7.5 days [IQR, 4.25-12.75 days]) or after 5 days (7 days [IQR, 5-10 days]) (P < .05). We found that the duration of viral shedding from NAI therapy was the shortest in spring 2013 (5.5 days) and the longest in winter-spring 2016-2017 (8.5 days) (P < .05), showing a prolonged trend. Conclusions Early NAI therapy within 2 days of illness shortened the duration of viral shedding and improved survival in patients with H7N9 viral infection.read more
Citations
More filters
Journal ArticleDOI
Factors Associated With Prolonged Viral Shedding in Patients With Avian Influenza A(H7N9) Virus Infection
Yeming Wang,Yeming Wang,Qiang Guo,Zheng Yan,Daming Zhou,Wei Zhang,Shujun Zhou,Yuping Li,Jing Yuan,Timothy M. Uyeki,Xinghua Shen,Wenjuan Wu,Hui Zhao,Yunfu Wu,Jia Shang,Zhengguang He,Yi Yang,Hongsheng Zhao,Yongqing Hong,Zehua Zhang,Min Wu,Tiemin Wei,Xilong Deng,Yijun Deng,Li-hua Cai,Weihua Lu,Hongmei Shu,Lin Zhang,Hong Luo,Y ing Zhou,Heng Weng,Keyi Song,Li Yao,Mingguang Jiang,Boliang Zhao,Ruibin Chi,Boqi Guo,Lin Fu,Long Yu,Haiyan Min,Pu Chen,Shuifang Chen,Liang Hong,Wei Mao,Xiaoping Huang,Lijun Gu,Hui Li,Hui Li,Chen Wang,Chen Wang,Chen Wang,Bin Cao,Bin Cao +52 more
TL;DR: These findings suggest that NAI treatment should be started as soon as possible in patients with suspected A(H7N9) infection and that use of corticosteroids should be prudent.
Journal ArticleDOI
Neutrophil-lymphocyte ratio as an early new marker in AIV-H7N9-infected patients: a retrospective study.
Yan Zhang,Pengfei Zou,Hai-nv Gao,Meifang Yang,Ping Yi,Jianhe Gan,Yinzhong Shen,Weihong Wang,Wenhong Zhang,Jun Li,Peng Liu,Lanjuan Li +11 more
TL;DR: The study found that NLR was independently associated with fatality, and is potentially a predictive prognostic biomarker in patients infected with the AIV-H7N9 influenza virus.
Journal ArticleDOI
Lopinavir/ritonavir and interferon combination therapy may help shorten the duration of viral shedding in patients with COVID-19: A retrospective study in two designated hospitals in Anhui, China.
TL;DR: Early initiation of lopinavir/ritonavir + IFN‐α combination therapy may help shorten the duration of SARS‐CoV‐2 shedding, causing increased hospital stays and medical costs.
Journal ArticleDOI
Novel Avian Influenza A Virus Infections of Humans.
Timothy M. Uyeki,Malik Peiris +1 more
TL;DR: A high index of suspicion and early diagnosis of avian influenza A virus infection is essential reduce transmission risk and support supportive care of complications.
Journal ArticleDOI
Research progress on human infection with avian influenza H7N9
TL;DR: The clinical and epidemiological characteristics of H7n9, the key gene mutations of the virus, and H7N9 vaccine are reviewed, thus providing a scientific basis for further monitoring and prevention of H 7N9 influenza epidemics.
References
More filters
Journal ArticleDOI
Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
Rongbao Gao,Bin Cao,Yunwen Hu,Zijian Feng,Dayan Wang,Wanfu Hu,Jian Chen,Zhijun Jie,Haibo Qiu,Ke Xu,Xuewei Xu,Hongzhou Lu,Wenfei Zhu,Zhancheng Gao,Nijuan Xiang,Yinzhong Shen,Zebao He,Y. Gu,Zhiyong Zhang,Yi Yang,Xiang Zhao,Lei Zhou,Xiaodan Li,Shumei Zou,Ye Zhang,Xiyan Li,Lei Yang,Junfeng Guo,Jie Dong,Qun Li,Libo Dong,Yun Zhu,Tian Bai,Shiwen Wang,Pei Hao,Weizhong Yang,Yanping Zhang,Jun Han,Hongjie Yu,Dexin Li,George F. Gao,Guizhen Wu,Yu Wang,Zhenghong Yuan,Yuelong Shu +44 more
TL;DR: Novel reassortant H7N9 viruses were associated with severe and fatal respiratory disease in three patients, and all three patients died.
Journal ArticleDOI
Neuraminidase Inhibitors for Influenza
TL;DR: The potential for the development of resistance especially limits the use of the adamantanes for the treatment of influenza, although the drugs still have a place in planning for prophylaxis during an epidemic.
Journal ArticleDOI
Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome
Yu Chen,Weifeng Liang,Shigui Yang,Nanping Wu,Hainv Gao,Jifang Sheng,Hangping Yao,Jianer Wo,Qiang Fang,Dawei Cui,Yongcheng Li,Xing Yao,Yun-Tao Zhang,Haibo Wu,Shufa Zheng,Hongyan Diao,Shichang Xia,Yanjun Zhang,Kwok-Hung Chan,Hoi-Wah Tsoi,Jade Lee-Lee Teng,Wenjun Song,Pui Wang,Siu-Ying Lau,Min Zheng,Jasper Fuk-Woo Chan,Kelvin K. W. To,Honglin Chen,Lanjuan Li,Kwok-Yung Yuen +29 more
TL;DR: Cross species poultry-to-person transmission of this new reassortant H7N9 virus is associated with severe pneumonia and multiorgan dysfunction in human beings and monitoring of the viral evolution and further study of disease pathogenesis will improve disease management, epidemic control, and pandemic preparedness.
Journal ArticleDOI
Kinetics of Influenza A Virus Infection in Humans
Prasith Baccam,Catherine A. A. Beauchemin,Catherine A. Macken,Frederick G. Hayden,Alan S. Perelson +4 more
TL;DR: A series of mathematical models of increasing complexity, which incorporate target cell limitation and the innate interferon response, are utilized to examine influenza A virus kinetics in the upper respiratory tracts of experimentally infected adults to suggest that antiviral treatments have a large hurdle to overcome in moderating symptoms and limiting infectiousness.
Journal ArticleDOI
Epidemiology of Human Infections with Avian Influenza A(H7N9) Virus in China
Qun Li,Lei Zhou,Minghao Zhou,Zhiping Chen,Furong Li,Huanyu Wu,Nijuan Xiang,Enfu Chen,Fenyang Tang,Dayan Wang,Ling Meng,Zhiheng Hong,Wenxiao Tu,Yang Cao,Leilei Li,Fan Ding,Bo Liu,Mei Wang,Rongheng Xie,Rongbao Gao,Xiaodan Li,Tian Bai,Shumei Zou,Jun He,Jiayu Hu,Yangting Xu,Chengliang Chai,Shiwen Wang,Yongjun Gao,Lianmei Jin,Yanping Zhang,Huiming Luo,Hongjie Yu,Jianfeng He,Qi Li,Xianjun Wang,Lidong Gao,Xinghuo Pang,Guohua Liu,Yansheng Yan,Hui Yuan,Yuelong Shu,Weizhong Yang,Yu Wang,Fan Wu,Timothy M. Uyeki,Zijian Feng +46 more
TL;DR: Most persons with confirmed H7N9 virus infection had severe lower respiratory tract illness, were epidemiologically unrelated, and had a history of recent exposure to poultry.
Related Papers (5)
Clinical findings in 111 cases of influenza A (H7N9) virus infection
Hainv Gao,Hongzhou Lu,Bin Cao,Bin Du,Hong Shang,Jianhe Gan,Shuihua Lu,Yida Yang,Qiang Fang,Yinzhong Shen,Xiuming Xi,Qin Gu,Xian-Mei Zhou,Hong-Ping Qu,Zheng Yan,Fang-Ming Li,Wei Zhao,Zhancheng Gao,Guang-Fa Wang,Lingxiang Ruan,Weihong Wang,Jun Ye,Hui-Fang Cao,Xingwang Li,Wenhong Zhang,Xu-Chen Fang,Jian He,Weifeng Liang,Juan Xie,Mei Zeng,Xianzheng Wu,Jun Li,Qi Xia,Zhao-Chen Jin,Qi Chen,Chao Tang,Zhiyong Zhang,Bao-Min Hou,Zhi-Xian Feng,Jifang Sheng,Nanshan Zhong,Lanjuan Li +41 more
Epidemiology of avian influenza A H7N9 virus in human beings across five epidemics in mainland China, 2013–17: an epidemiological study of laboratory-confirmed case series
Xiling Wang,Hui Jiang,Peng Wu,Timothy M. Uyeki,Luzhao Feng,Shengjie Lai,Lili Wang,Xiang Huo,Ke Xu,Enfu Chen,Xiaoxiao Wang,Jianfeng He,Min Kang,Renli Zhang,Jin Zhang,Jiabing Wu,Shixiong Hu,Hengjiao Zhang,Xiaoqing Liu,Weijie Fu,Jianming Ou,Shenggen Wu,Ying Qin,Zhijie Zhang,Yujing Shi,Juanjuan Zhang,Jean Artois,Vicky J. Fang,Hongbo Zhu,Yi Guan,Marius Gilbert,Peter Horby,Gabriel M. Leung,George F. Gao,George F. Gao,Benjamin J. Cowling,Hongjie Yu +36 more
Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus
Rongbao Gao,Bin Cao,Yunwen Hu,Zijian Feng,Dayan Wang,Wanfu Hu,Jian Chen,Zhijun Jie,Haibo Qiu,Ke Xu,Xuewei Xu,Hongzhou Lu,Wenfei Zhu,Zhancheng Gao,Nijuan Xiang,Yinzhong Shen,Zebao He,Y. Gu,Zhiyong Zhang,Yi Yang,Xiang Zhao,Lei Zhou,Xiaodan Li,Shumei Zou,Ye Zhang,Xiyan Li,Lei Yang,Junfeng Guo,Jie Dong,Qun Li,Libo Dong,Yun Zhu,Tian Bai,Shiwen Wang,Pei Hao,Weizhong Yang,Yanping Zhang,Jun Han,Hongjie Yu,Dexin Li,George F. Gao,Guizhen Wu,Yu Wang,Zhenghong Yuan,Yuelong Shu +44 more