Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
Citations
More filters
Journal ArticleDOI
N-[(3-Bromo-1-phenylsulfonyl-1H-indol-2-yl)methyl]-4-fluoroaniline
TL;DR: In this paper, the indole ring system of C21H16BrFN2O2S makes dihedral angles of 87.23 and 77.58 degrees with the fluorobenzene and phenyl rings, respectively.
Journal ArticleDOI
Crystal structure of 1-(5-bromo-2-(4-methoxyphenyl)-1H-indol-7-yl)ethanone oxime, C17H15BrN2O2
Abstract: Abstract C17H15BrN2O2, monoclinic, P21/c, a = 14.4197(9) Å, b = 7.5423(5) Å, c = 14.9602(9) Å, β = 114.665(2)°, V = 1478.59(16) Å3, Z = 4, Rgt(F) = 0.0196, wRref(F2) = 0.0526, T = 173(2) K.
Research Article Facile Transformation of Cinnolines into Indoles
TL;DR: In this article, a single step conversion of some cinnolines into indoles by ring transformation reaction was reported, and nitrogen extrusion from the former has been carried out by the application of Zn/CH3COOH.
Journal ArticleDOI
Synthesis of Novel Hybrid Scaffolds of Pyran Chalcone Derivatives Bearing Indole and Pyrrole Rings
TL;DR: In this article, a series of novel hydroxy-pyran-chalcone hybrid compounds 4(a-b), 5 (a-f), 7(a) and 8(a)-f) has been synthesized by employing simple methods in various approaches through convergent synthetic strategies.
Journal ArticleDOI
Do we need a replacement medication for influenza with good efficacy
TL;DR: In the first quarter of 2014, the independent, non-profit and non-governmental organization reported that Tamiflu (with the generic name of Oseltamivir) is not working effectively and was causing side effects including vomiting, nausea, headache, renal problems, psychiatric events, and the risk of other serious complications when used for the treatment and prophylaxis of influenza as discussed by the authors.
References
More filters
Journal ArticleDOI
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
Journal ArticleDOI
Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
Journal ArticleDOI
Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
Journal ArticleDOI
Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
Journal ArticleDOI
Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.