Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
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3-Naphthylindoles as new promising candidate antioxidant, antibacterial, and antibiofilm agents
TL;DR: Several 3-naphthylindole analogues were synthesized by direct arylation of 1-diazonaphthalene-2-(1H)-ones by rhodium(II)-catalyzed cross-coupling reaction and their antioxidant and antibacterial properties evaluated and among the analogues tested, compound 3m displayed the highest antioxidant activity.
Journal ArticleDOI
BF3 etherate-mediated microwave-assisted facile synthesis of thiopyrano[2,3-b]indol-2-one
TL;DR: In this article, a facile synthesis of indole annulated 2H-thiopyran-2-ones has been developed by condensation of indoline 2-thiones with acetoacetic esters in the presence of borontrifluoride etherate (BF3 etherate).
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Synthesis of Functionalised Indoline and Isoquinoline Derivatives through a Silylcarbocyclisation/Desilylation Sequence
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Microwave-assisted synthesis and myorelaxant activity of 9-indolyl-1,8-acridinedione derivatives.
Miyase Gözde Gündüz,Fatma Isli,Ahmed El-Khouly,Şeniz Yıldırım,Gökçe Sevim Öztürk Fincan,Rahime Şimşek,Cihat Şafak,Yusuf Sarioglu,Sema Öztürk Yildirim,Sema Öztürk Yildirim,Ray J. Butcher +10 more
TL;DR: In this study a microwave-assisted method was applied for the synthesis of novel 9-(substituted indolyl)-3,4,6,7-tetrahydroacridine-1,8-(2H,5H,9H,10H)-dione derivatives, and results indicated that some compounds and pinacidil produced concentration-dependent relaxation on the strips.
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Gold-Catalyzed Synthesis of 6-Hydroxyindoles from Alkynylcyclohexadienones and Substituted Amines
TL;DR: An efficient gold-catalyzed formation of 6-hydroxy indoles from substituted alkynyl cyclohexadienones and amines has been developed, which tolerates a range of substitutions and resulted 6-Hydroxy indole derivatives selectively.
References
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Journal ArticleDOI
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
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Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
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Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
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Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.