Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
Citations
More filters
Journal ArticleDOI
Computer-aided discovery of bis-indole derivatives as multi-target drugs against cancer and bacterial infections: DFT, docking, virtual screening, and molecular dynamics studies
TL;DR: Eight potential drugs, of which three as multi-target agents against both bacteria and cancer, are shortlisted, can be envisaged to emerge as very effective drugs for cancers and bacterial infections, which encourages experimental studies to validate them.
Journal ArticleDOI
Novel Multitarget Directed Triazinoindole Derivatives as Anti-Alzheimer Agents.
Dushyant V. Patel,Nirav R. Patel,Ashish M. Kanhed,Sagar P. Patel,Anshuman Sinha,Deep D. Kansara,Annie R. Mecwan,Sarvangee B. Patel,Pragnesh N. Upadhyay,Kishan B Patel,Dharti B. Shah,Navnit K Prajapati,Prashant R. Murumkar,Kirti V. Patel,Mange Ram Yadav +14 more
TL;DR: Findings project compound 23e as a potential balanced MTDL in the evolution process of novel anti-AD drugs and significant interactions of 23e within the active sites of AChE as well as BuChE.
Journal ArticleDOI
Cu-Catalyzed Directed C7−H Imidation of Indolines via Cross-Dehydrogenative Coupling
Journal ArticleDOI
Nickel-Catalyzed trans-Carboamination across Internal Alkynes to Access Multifunctionalized Indoles
TL;DR: A Ni-catalyzed reaction was developed for the synthesis of multifunctionalized indoles that could be successfully transformed to functionalized carbazoles.
Journal ArticleDOI
Directed synthesis and immunoactive properties of (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanyl(sulfonyl)alkanecarboxylic acids
Mirskova Anna N,Galina G. Levkovskaya,O. P. Kolesnikova,O. M. Perminova,Elena V. Rudyakova,Sergey N. Adamovich +5 more
TL;DR: In this article, a general method for the synthesis of 1-alkyl(allyl)(benzyl)-substituted (indol-3-yl)-sulfanylalkanecarboxylic acids and hexane-1,6-diyl(1,4-phenylenemethylene)bisindol, 3-ylsulfonyl-sulfanosyclic acids from the corresponding N-substitized indoles and bisindoles, thiourea, iodine, and halogencarboxy
References
More filters
Journal ArticleDOI
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
Journal ArticleDOI
Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
Journal ArticleDOI
Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
Journal ArticleDOI
Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
Journal ArticleDOI
Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.