Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
Citations
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MoO2Cl2 catalyzed efficient synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones and polyhydroquinolines: recyclability, fluorescence and biological studies
Sravanthi Devi Guggilapu,Santosh Kumar Prajapti,Atulya Nagarsenkar,Guntuku Lalita,Ganga Modi Naidu Vegi,Bathini Nagendra Babu +5 more
TL;DR: This is the first report of exploring Lewis acid properties of MoO2Cl2 in the diversity oriented synthesis of Biginelli and Hantzsch reactions and demonstrates the exceptional tolerance towards acid labile protecting groups such as tert-butyl dimethyl silyl (TBDMS).
Journal ArticleDOI
Recent applications of Rose Bengal catalysis in N-heterocycles: a short review
TL;DR: In this paper, a review of the synthetic potential of Rose Bengal for synthesis and site selective functionalization of nitrogen containing heterocycles is presented, where the most significant results are bond creation, bond functionalization, and cross couplings.
Journal ArticleDOI
Controlling Regioselectivity in the Enantioselective N‐Alkylation of Indole Analogues Catalyzed by Dinuclear Zinc‐ProPhenol
TL;DR: The chiral aminals were further elaborated into various chiral polyheterocyclic derivatives and the surprising stability of the chiral N-alkylation products will open new windows for asymmetric catalysis and medicinal chemistry
Journal ArticleDOI
Indole Synthesis via Cyclative Formation of 2,3-Dizincioindoles and Regioselective Electrophilic Trapping
TL;DR: This conversion of 2-ethynylaniline to 2,3-dimetalloindole can be applied to an expeditious synthesis of indenoindolone and benzodipyrrole derivatives, which are compounds of interest for medicinal chemistry and materials science, respectively.
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Indolylmethylene benzo[h]thiazolo[2,3-b]quinazolinones: synthesis, characterization and evaluation of anticancer and antimicrobial activities.
Rajitha Gali,Janardhan Banothu,Mahendar Porika,Ravibabu Velpula,Sairengpuii Hnamte,Rajitha Bavantula,Sadanandam Abbagani,Siddhardha Busi +7 more
TL;DR: A series of novel 10-((1H-indol-3-yl)methylene)-7-aryl-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-ones have been synthesized in good yields and have shown significant antibacterial and comparable antifungal activities against all the tested microorganisms.
References
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Journal ArticleDOI
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
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Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
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Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
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Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.