Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
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Synthesis of Indoles and Benzofurans Using a Graphene Oxide-Grafted Aminobisphosphine–PdII Complex
TL;DR: Indoles and benzofurans have been synthesized using a graphene oxide-grafted aminobisphosphine–PdII complex (GO@PNP-Pd) under copper-free condition and the recycling ability of the immobilized catalyst has been examined for five consecutive runs with appreciable conversion.
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Palladium-catalyzed carbonylative cyclization of 2-alkynylanilines and aryl iodides to access N-acyl indoles
TL;DR: A palladium-catalyzed carbonylative synthesis of N-acyl indoles from 2-alkynylanilines and aryl iodides has been developed in a facile manner with high yields.
Journal ArticleDOI
Synthesis of Indole-Fused Polycyclics via Rhodium-Catalyzed Undirected C-H Activation/Alkene Insertion.
TL;DR: A Rh(III)-catalyzed undirected C-H activation/alkene insertion to synthesize diversified indole-fused polycyclics has been developed.
Journal ArticleDOI
Silver-Catalyzed Three-Component Coupling Reaction of Amines, 2-Isocyanobenzaldehydes, and 2,2,2-Trifluorodiazoethane and Synthesis of Trifluoromethyl-Substituted Indolo[1,2-c]quinazolines
Journal ArticleDOI
Metal‐Free [3+2] Tandem Cyclization Synthesis of Unique 11H‐Pyrido[3′,2′:4,5]Pyrrolo[3,2‐b]Indolizine from 7‐Azaindoles and Pyridotriazoles
TL;DR: The metal-free, green and highly atom-economic formal [3+2] tandem cyclization is ideal for sustainable reaction development as mentioned in this paper, which can be employed to synthesize unique 11H-pyrido[3,2:4,5]pyrrolo[ 3,2-b]indolizines from 7-azaindoles and pyridotriazoles through a TsOH-induced efficient process.
References
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Journal ArticleDOI
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
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Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
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Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
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Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.