Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
Citations
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Synthesis of indole-cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process.
Muthumani Muthu,Rakkappan Vishnu Priya,Abdulrahman I. Almansour,Raju Suresh Kumar,Raju Ranjith Kumar +4 more
TL;DR: The one-pot four-component reaction of 3-(1H-indol-3-yl)-3-oxopropanenitriles, aromatic aldehydes, cycloalkanones and ammonium acetate occurred via a six-step tandem Knoevenagel condensation–nucleophilic addition to carbonyl–Michael addition–N-cyclization–elimination–air oxidation sequence to afford structurally intriguing indole–cycloalk
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Synthesis, cytotoxicity and docking studies (with SARS-CoV-2) of water-soluble binuclear Ru-p-cymene complex holding indole thiosemicarbazone ligand
Jebiti Haribabu,Nithya Balakrishnan,Srividya Swaminathan,Jerome Peter,Jerome Peter,Dasararaju Gayathri,Cesar Echeverria,Nattamai Bhuvanesh,Ramasamy Karvembu +8 more
TL;DR: A water-soluble binuclear organometallic Ru-p-cymene complex [Ru(η6p-cyclmene)(η2-L)]2 (1) was prepared from (E)-2-((1H-indol-3-yl)methylene)-N-phenylhydrazine-1-carbothioamide (HL) and [RuCl2(p-cymene)]2 in methanol at room temperature under inert atmosphere.
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A general approach to substituted 6H-pyrido[2′,3′:5,6] [1,3]oxazino[3,4-a]indole via cyclization from an indoline precursor followed by re-aromatization
Shuwen He,Peng Li,Xing Dai,Casey Cameron Mccomas,Hongling Huang,Chaoliang Zhan,Liang Chang,Yuehui Liu,Shaojun Chen,Zhong Lai,Hong Liu,Jingjun Yin,Qun Dang,Dong Xiao,Nicolas Zorn,Xuanjia Peng,Ravi P. Nargund,Anandan Palani +17 more
TL;DR: In this paper, a general method for the synthesis of the substituted 6H-pyrido[2′,3′:5,6] [1,3]oxazino[3,4-a]indole ring system via cyclization from an indoline precursor with aldehydes or ketones followed by oxidative re-aromatization is presented.
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Synthesis of New Functionalized Indoles Based on Ethyl Indol-2-carboxylate
TL;DR: Successful alkylations of the nitrogen of ethyl indol-2-carboxylate and N-alkylated esters were carried out using aq.
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Estimation of biological affinity of nitrogen-containing conjugated heterocyclic pharmacophores
Marina Kachaeva,Nataliya Obernikhina,Evgenia S. Veligina,Maryna Zhuravlova,Yaroslav Prostota,Oleksiy Kachkovsky,Volodymyr Brovarets +6 more
TL;DR: In this work, a series of widely known heterocyclic compounds, as well as derivatives of oxazole and nucleobases are analyzed in detail and it is shown that change in φ0 index is connected to the biological activity.
References
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Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
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Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
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Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
Journal ArticleDOI
Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.