Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
Citations
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Synthesis and Cytotoxicity Evaluation of New 3‐substituted 4‐(4‐methyloxy phenyl)‐1H‐Pyrrole Derivatives
TL;DR: Because the developed pyrrole derivatives showed strong anticancer activity and high selectivity, this new series of pyr Role derivatives could be considered as promising lead compounds for further development of potent and safe anticancer agents.
Journal ArticleDOI
Organocatalytic asymmetric cascade cyclization reaction of o-hydroxy cinnamaldehydes with diphenylphosphine oxide
TL;DR: In this article, a highly stereoselective asymmetric cascade cyclization reaction between o-hydroxycinnamaldehydes and diphenylphosphine oxide has been achieved with 84%-99% ee and 7:1-20:1 dr under the catalysis of l -diarylprolinol silyl ether.
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Ester-Derivatized indoles as fluorescent and infrared probes for hydration environments†
TL;DR: The authors' measurements provide a guide for choosing esterderivatized indoles to use in practice and data for computational modeling of the effect of substitution on the electronic transitions of indole.
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Novel Indole‐Quinazolinone Based Amides as Cytotoxic Agents
TL;DR: Indole-quinazolinone hybrids with active amides were synthesized, characterized, and assessed for their cytotoxicity and showed substantial activity in sulphorhodamine B assay method.
Journal ArticleDOI
Trifluoroethanol-promoted ring-opening cyclization of 4-(2-oxiranylmethoxy)indoles: access to 4,5-fused indoles
Jonali Das,Sajal Kumar Das +1 more
TL;DR: In this article, the trifluoroethanol-mediated ring-opening cyclization of readily accessible 4-(2-oxiranylmethoxy)indoles takes place in a diastereoselective and 6-end fashion to generate pyrano[2,3-e]indol-3-ols in high yields.
References
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Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
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Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
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Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
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Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.