Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
Citations
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Synthesis and Anticonvulsant Activity of Indolo-Imidazolone HybridMolecules
TL;DR: A series of hybrid molecules comprising of indole and imidazolone moieties (4a-g and 5a,b) was synthesized with a view to obtaining promising anticonvulsant molecules.
Journal ArticleDOI
A novel method for the synthesis of 3-aminoindoles using iodine and Cs2CO3 as catalyst
TL;DR: In this paper, a facile, efficient and one-pot two component reaction for the synthesis of 3-aminoindole was performed under green conditions and products were obtained in good yields.
Synthesis and Crystal Structure of 3-{4-[(4-(2-Oxo-2,3-dihydro-1H-benzilimidazol-1-yl)piperidin-1-yl)benzyl]}-2-phenylindole
Jean Guillon,Marian Vincenzi,Luisa Ronga,Filomena Rossi,Solène Savrimoutou,Stéphane Moreau,M and Marchivie +6 more
TL;DR: The X-ray crystal structure of 3-{4]-(4-(2-oxo-2,3-dihydro-1H-benzimidazol- 1-yl)piperidin-1yl)benzyl, a compound that showed high cytotoxic potential against various leukemia cell lines, was established.
Journal ArticleDOI
Synthesis, crystal studies and pharmacological role prediction of 3-iodo-2- methyl-1 phenyl sulfonyl-1h indole
TL;DR: It is suggested that the crystallized indole-based ligand may have antitubercular, antibacterial, and antimelanoma activities with respect to the targets considered.
References
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Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
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Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
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Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
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Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.