Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
Citations
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N-Heterocyclic Carbene-Catalyzed [3+3] Annulation of Indoline-2-thiones with Bromoenals: Synthesis of Indolo[2,3-b]dihydrothiopyranones
TL;DR: The N-heterocyclic carbene-catalyzed [3+3] annulation of indoline-2-thiones and bromoenals has been developed, giving the corresponding indolo[2,3-b]dihydrothiopyranones in high yields as discussed by the authors.
Journal ArticleDOI
Indigoid dyes by group E monooxygenases: mechanism and biocatalysis
TL;DR: Group E monooxygenase can be an alternative biocatalyst for the biosynthesis of indigoid dyes and it was possible for the first time to show that the product of the enzymatic reaction is an epoxide.
Journal ArticleDOI
3-(4-Chlorophenylselanyl)-1-methyl-1H-indole, a new selenium compound elicits an antinociceptive and anti-inflammatory effect in mice.
Paloma Taborda Birmann,Fernanda Severo Sabedra Sousa,Daniela H. de Oliveira,Micaela Domingues,Beatriz Vieira,Eder J. Lenardão,Lucielli Savegnago +6 more
TL;DR: The results demonstrate that the antinociceptive effect of CMI is mediated by monaminergic, opioidergic and adenosinergic modulations and can be a promising molecule capable of modulating different pathways for the treatment of pain and inflammation.
Journal ArticleDOI
An acid-promoted novel skeletal rearrangement initiated by intramolecular ipso-Friedel-Crafts-type addition to 3-alkylidene indolenium cations.
TL;DR: An acid-promoted novel skeletal rearrangement is described, using trifluoroacetic acid as the acid promoter, and producing tricyclic indole derivatives.
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Zinc(II) complexes of indole thiosemicarbazones: DNA/protein binding, molecular docking and in vitro cytotoxicity studies
Nithya Balakrishnan,Jebiti Haribabu,Jebiti Haribabu,Dhanabalan Anantha Krishnan,Srividya Swaminathan,Dharmasivam Mahendiran,Nattamai Bhuvanesh,Ramasamy Karvembu +7 more
TL;DR: Four Zn(II) complexes (1–4) featuring indole thiosemicarbazones were synthesized and well-characterized by elemental analyses and various spectroscopic techniques, which implied that the complexes bound to CT DNA via intercalation, and complex 4 showed a higher binding affinity than the other complexes.
References
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Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
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Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
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Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
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Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.