Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
Citations
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Journal ArticleDOI
Synthesis and Structure of Geminally Activated Nitroethenes of the Indole Series
Ruslan I. Baichurin,A. A. Fedorushchenko,N. I. Aboskalova,L. V. Baichurina,A. V. Fel’gendler,S. V. Makarenko +5 more
TL;DR: A series of 2-(indol-3-yl)-1-nitroethenes containing an ester, acetyl, benzoyl, or cyano group in the geminal position with respect to the nitro group have been synthesized, and their structure has been studied by 1H, 13C−{1H} NMR, IR, and UV spectroscopy as mentioned in this paper.
Patent
Indole-3-carbinol derivatives
Modi Rajiv Indravadan,Chandan Hardhan Singh,Niravkumar Sureshbhai Sagar,Sunilkumar Ramsuratbhai Tivari,Bipin Dhanajibhai Gadhiya +4 more
TL;DR: In this paper, a stable indole-3-carbinol derivatives of Formula-I and its pharmaceutical composition and biological activity are described. The present invention includes compositions and methods for the treatment and prevention of conditions associated with Inflammation.
Journal ArticleDOI
Synthesis, Characterization, Crystal Studies of (E)-3-(3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl) Acrylaldehyde
TL;DR: In this article, single crystals of the title compound (E)-3-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl) were synthesized and developed.
Journal ArticleDOI
Synthesis and identification of new cytosine-derived compounds and study their binding with DNA
TL;DR: In this article, the effect of compound binding with CT-DNA from groove minor sides, was concluded from studying FT-IR spectrum, which was done by using FTIR and UVVisible techniques.
Journal ArticleDOI
Bimetallic Iron-Palladium Catalyst System as a Lewis-Acid for the Synthesis of Novel Pharmacophores Based Indole Scaffold as Anticancer Agents.
Mohammad Shahidul Islam,Monaam Ben Ali,Abdullah Mohammed Al-Majid,Abdullah Saleh Alamary,Saeed Alshahrani,Sammer Yousuf,Muhammad Iqbal Choudhary,Assem Barakat,Assem Barakat +8 more
TL;DR: The Friedel-Crafts reaction between substituted indoles as nucleophiles with chalcones-based benzofuran and benzothiophene scaffolds was carried out by employing a highly efficient bimetallic iron-palladium catalyst system.
References
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Journal ArticleDOI
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
Journal ArticleDOI
Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
Journal ArticleDOI
Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
Journal ArticleDOI
Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.