Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
Citations
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Benzisothiazolones arrest the cell cycle at the G2/M phase and induce apoptosis in HeLa cells
TL;DR: Anticancer activities of a series of benzisothiazolones having alkyl, aryl and aralkyl substituents on the nitrogen atom and the mechanistic basis of cytotoxicity are presented.
Journal ArticleDOI
Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.
Ahmed Elkamhawy,Ahmed Elkamhawy,Sora Paik,Hyeon Jeong Kim,Hyeon Jeong Kim,Jong Hyun Park,Ashwini M. Londhe,Ashwini M. Londhe,Kyeong Lee,Ae Nim Pae,Ae Nim Pae,Ki Duk Park,Ki Duk Park,Ki Duk Park,Eun Joo Roh,Eun Joo Roh +15 more
TL;DR: The remarkable MAO-B inhibitory activity of 4e (N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide), with its selectivity and competitive inhibition, advocates its potential role as a promising lead worthy of further optimization.
Journal ArticleDOI
Direct use of allylic alcohols for palladium-catalyzed synthesis of 3-allylbenzo[b]thiophenes, benzofurans and indoles in aqueous media
Yogesh Daulat Dhage,Tsukasa Shirai,Miho Arima,Arisa Nakazima,Hidemasa Hikawa,Isao Azumaya Taichi Kusakabe,Keisuke Takahashi,Keisuke Kato +7 more
TL;DR: In this article, the allylative cyclization of (o-alkynylphenyl) (methoxymethyl) sulfides, oalkynylanilines, and o-alkylphenols catalyzed by π-allyl palladium species generated from simple allylic alcohols was described.
Journal ArticleDOI
Isatin derivatives in reactions with phosphorus(III-V) compounds.
TL;DR: In this review, generalize and analyze information about reactions between isatin and three-, four-, and five-coordinate phosphorus compounds, published between 1966 and 2014.
Journal ArticleDOI
Exploring indole-based-thiadiazole derivatives as potent acetylcholinesterase and butyrylcholinesterase enzyme inhibitors.
Muhammad Taha,Fazal Rahim,Nizam Uddin,Ihsan Ullah Khan,Naveed Iqbal,El Hassane Anouar,Mohammed Salahuddin,Rai Khalid Farooq,Mohammed Gollapalli,Khalid Mohammed Khan,Ameeduzzafar Zafar +10 more
TL;DR: Indole based thiadiazole derivatives (1-18) were synthesized and evaluated for their acetylcholinesterase (AChE) and butyrylcholine-choline (BChE), and the IC50 values of the synthesized analogues ranging between 0.17-±-0.05 to 33.6-μm were obtained as mentioned in this paper.
References
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Journal ArticleDOI
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
Journal ArticleDOI
Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
Journal ArticleDOI
Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
Journal ArticleDOI
Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.