Journal ArticleDOI
Biological importance of the indole nucleus in recent years: A comprehensive review
TLDR
Indole has a benzene ring and pyrrole ring sharing one double bond and is a heterocyclic system with 10 electrons from four double bonds and the lone pair from the nitrogen atom as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2010-05-01. It has received 385 citations till now. The article focuses on the topics: Indole test & Ring (chemistry).read more
Citations
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Synthesis of C4-Substituted Indoles via a Catellani and C-N Bond Activation Strategy.
Bo-Sheng Zhang,Fan Wang,Ying-Hui Yang,Xue-Ya Gou,Yi-Feng Qiu,Xicun Wang,Yong-Min Liang,Yuke Li,Zheng-Jun Quan +8 more
TL;DR: This paper describes the case of a cross study between the C-N bond cleavage reaction field and the Catellani-Lautens reaction system and a series of highly functionalized C4-substituted indoles were synthesized using this strategy.
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Facile synthesis of 2-arylmethylindoles and 2-vinylic indoles through palladium-catalyzed heteroannulations of 2-(2-propynyl)aniline and 2-(2-propynyl)tosylanilide
TL;DR: A facile method for the general synthesis of 2-arylmethylindoles has been developed through the reaction of 2-(2-propynyl)aniline or 2-propYNyl)tosylanilide with aryl iodides in the presence of Pd(OAc)2, PPh3, and DBU.
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Zinc oxide-NP catalyzed direct indolation of in situ generated bioactive tryptanthrin
TL;DR: A ZnO-NP catalyzed direct indolation of in situ generated tryptanthrin via C–H functionalization and C–C bond formation has been developed and effectively utilized to accomplish the synthesis of 6-hydroxy-6-(1H-indol-3-yl)indolo[2,1-b]quinazolin-12(6H)-one derivatives in good to excellent yields with high product selectivity.
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ZrO2 nanoparticles as a reusable solid dual acid-base catalyst for facile one-pot synthesis of multi-functionalized spirooxindole derivatives under solvent free condition
TL;DR: In this paper, a two-step one-pot protocol for the facile synthesis of biologically important spirooxindole derivatives such as spiro[4H-pyran-3,3′-oxindoles] and spiro [indoline]-3,4′(1H′)-pyrano-[2,3-c]pyrazol-2-ones has been developed.
Journal ArticleDOI
Interconnections between dissociative electron attachment and electron-driven biological processes
TL;DR: The present review summarises the results of studies on the correlation between the biological activity of various classes of compounds and fragment species formed by DEA, and identifies the fragment species detected with DEA of importance for understanding the metabolism of xenobiotics, including side effects produced by drugs.
References
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Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents.
TL;DR: The newly synthesized compounds were found to possess potential anti-inflammatory and analgesic activities and to be compatible with existing thiazolidin-4-one derivatives.
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Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives
Nilgün Karalı,Aysel Gürsoy,Fatma Kandemirli,Nathaly Shvets,F. Betül Kaynak,Süheyla Özbey,Vasyl Kovalishyn,Anatholy Dimoglo,Anatholy Dimoglo +8 more
TL;DR: The antituberculosis activity of molecules with diverse skeletons was investigated by means of the Electronic-Topological Method (ETM) and Artificial Neural Networks were used after the ETM to obtain the algorithmic base for the activity prediction.
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Synthesis and antiinflammatory activity of heterocyclic indole derivatives.
TL;DR: The most active compound, 3-[1-acetyl-5-(p-hydroxyphenyl)-2-pyrazolin-3-yl]indole (7) was found to be most potent, which has shown higher percent of inhibition of oedema, lower ulcerogenic liability and acute toxicity than the standard drug phenylbutazone.
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Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.
TL;DR: An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen on indeno part showed effective antioxidant power.
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Indole and Isatin Oximes: Synthesis, Reactions, and Biological Activity. (Review)
TL;DR: In this article, data on methods for the production of isatin and indole aldoximes, ketoxime, and amidoximes and their reactions are reviewed, and individual syntheses of new heterocycles from indole and isatin oximes are discussed.