Cannabinoid receptor localization in brain
TLDR
The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in the in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience.Abstract:
[3H]CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific cannabinoid receptor in brain sections. The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in our in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience. Autoradiography of cannabinoid receptors in brain sections from several mammalian species, including human, reveals a unique and conserved distribution; binding is most dense in outflow nuclei of the basal ganglia--the substantia nigra pars reticulata and globus pallidus--and in the hippocampus and cerebellum. Generally high densities in forebrain and cerebellum implicate roles for cannabinoids in cognition and movement. Sparse densities in lower brainstem areas controlling cardiovascular and respiratory functions may explain why high doses of delta 9-tetrahydrocannabinol are not lethal.read more
Citations
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Cannabinoids: possible role in patho‐physiology and therapy of Gilles de la Tourette syndrome
TL;DR: The results provide more evidence that marijuana improves tics and behavioural disorders in TS and suggest that the cannabinoid system might play a major role in TS pathology.
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The role of cannabinoids in adult neurogenesis.
TL;DR: This timely review summarizes the evidence that the cannabinoid system is intricately associated with neuronal differentiation and maturation of NPCs and highlights intrinsic/extrinsic signalling mechanisms that are cannabinoid targets.
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CB1 Receptor Deficiency Decreases Wheel-Running Activity: Consequences on Emotional Behaviours and Hippocampal Neurogenesis
Sarah Dubreucq,Muriel Koehl,Muriel Koehl,Djoher Nora Abrous,Djoher Nora Abrous,Giovanni Marsicano,Giovanni Marsicano,Francis Chaouloff,Francis Chaouloff +8 more
TL;DR: It is suggested that mouse CB1 receptors control wheel running but not its neurogenic consequences in the hippocampus, which counteracted in a time-dependent manner the deficiency of extinction measured in CB1(-/-) mice.
Journal ArticleDOI
Marijuana Use and Cardiovascular Disease.
TL;DR: It is reasonable to recommend against recreational marijuana use, especially in individuals with a history of coronary artery disorders, and longitudinal studies have indicated that marijuana use may not have a significant effect on long-term mortality.
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Treatment of Tourette syndrome with delta-9-tetrahydrocannabinol (delta 9-THC): no influence on neuropsychological performance.
Kirsten R. Müller-Vahl,Heidrun Prevedel,Karen Theloe,Hans Kolbe,Hinderk M. Emrich,Udo Schneider +5 more
TL;DR: Results from this study corroborate previous data suggesting that in patients suffering from TS, treatment with Δ9-THC causes neither acute nor long-term cognitive deficits.
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