Cannabinoid receptor localization in brain
TLDR
The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in the in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience.Abstract:
[3H]CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific cannabinoid receptor in brain sections. The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in our in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience. Autoradiography of cannabinoid receptors in brain sections from several mammalian species, including human, reveals a unique and conserved distribution; binding is most dense in outflow nuclei of the basal ganglia--the substantia nigra pars reticulata and globus pallidus--and in the hippocampus and cerebellum. Generally high densities in forebrain and cerebellum implicate roles for cannabinoids in cognition and movement. Sparse densities in lower brainstem areas controlling cardiovascular and respiratory functions may explain why high doses of delta 9-tetrahydrocannabinol are not lethal.read more
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Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of Δ9-tetrahydrocannabinol on spatial memory.
Vasco C. Sousa,Natália Assaife-Lopes,Joaquim A. Ribeiro,Judith A. Pratt,Ros R. Brett,Ana M. Sebastião +5 more
TL;DR: A1 receptors exert a negative modulatory effect on CB1-mediated inhibition of GABA and glutamate release, and provides the first evidence of chronic caffeine-induced alterations on the cannabinoid system in the cortex and hippocampus, with functional implications in spatial memory.
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Differences in regional blood volume during a 28-day period of abstinence in chronic cannabis smokers
Jennifer T. Sneider,Jennifer T. Sneider,Harrison G. Pope,Harrison G. Pope,Marisa M. Silveri,Marisa M. Silveri,Norah S. Simpson,Staci A. Gruber,Staci A. Gruber,Deborah A. Yurgelun-Todd,Deborah A. Yurgelun-Todd +10 more
TL;DR: It is suggested that while CBV levels begin to normalize with continued abstinence from cannabis, specifically in frontal areas, other temporal and cerebellar brain regions show slower CBV decreases.
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The endocannabinoid system and Post Traumatic Stress Disorder (PTSD): From preclinical findings to innovative therapeutic approaches in clinical settings
TL;DR: A thorough overview of both animal and human studies investigating the effects of cannabinoids on memory processes is offered, and studies investigating cannabinoid modulatory influences on memory consolidation, retrieval and extinction will be presented, and the potential benefits associated with each approach will be discussed.
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Cannabinoid receptors in developing rats: detection of mRNA and receptor binding
TL;DR: Results indicate that cannabinoid receptor mRNA is present at adult levels as early as postnatal day 3, and suggest the possibility of a developmental progression for cannabinoid receptor development with receptor mRNA appearing first, followed by a period of rapid proliferation of the receptors themselves.
Journal ArticleDOI
Inhibition of salivary secretion by activation of cannabinoid receptors.
Juan Pablo Prestifilippo,Juan Pablo Prestifilippo,Javier Fernández-Solari,Javier Fernández-Solari,Carolina de la Cal,Maria Iribarne,Angela M. Suburo,Valeria Rettori,Samuel M. McCann,Juan C. Elverdin +9 more
TL;DR: The best-known endocannabinoid is anandamide (AEA), which binds with high affinity to CB1 and CB2 receptors, and it is concluded that AEA decreases saliva secretion in the SMG acting throughCB1 andCB2 receptors.
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