Cannabinoid receptor localization in brain
TLDR
The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in the in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience.Abstract:
[3H]CP 55,940, a radiolabeled synthetic cannabinoid, which is 10-100 times more potent in vivo than delta 9-tetrahydrocannabinol, was used to characterize and localize a specific cannabinoid receptor in brain sections. The potencies of a series of natural and synthetic cannabinoids as competitors of [3H]CP 55,940 binding correlated closely with their relative potencies in several biological assays, suggesting that the receptor characterized in our in vitro assay is the same receptor that mediates behavioral and pharmacological effects of cannabinoids, including human subjective experience. Autoradiography of cannabinoid receptors in brain sections from several mammalian species, including human, reveals a unique and conserved distribution; binding is most dense in outflow nuclei of the basal ganglia--the substantia nigra pars reticulata and globus pallidus--and in the hippocampus and cerebellum. Generally high densities in forebrain and cerebellum implicate roles for cannabinoids in cognition and movement. Sparse densities in lower brainstem areas controlling cardiovascular and respiratory functions may explain why high doses of delta 9-tetrahydrocannabinol are not lethal.read more
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HU-308: A specific agonist for CB2, a peripheral cannabinoid receptor
Lumir Hanus,Aviva Breuer,Susanna Tchilibon,S. Shiloah,D. Goldenberg,M. Horowitz,Roger G. Pertwee,Ruth A. Ross,Raphael Mechoulam,Ester Fride +9 more
TL;DR: HU-308 reduces blood pressure, blocks defecation, and elicits anti-inflammatory and peripheral analgesic activity, demonstrating the feasibility of discovering novel nonpsychotropic cannabinoids that may lead to new therapies for hypertension, inflammation, and pain.
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Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids.
TL;DR: This review covers recent developments in the cellular neurophysiology of retrograde signaling in the mammalian central nervous system and focuses on a group of molecules from different chemical classes that appear to act as retrograde messengers.
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Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction.
Deepak Cyril D'Souza,Walid M. Abi-Saab,Walid M. Abi-Saab,Steven Madonick,Kimberlee Forselius-Bielen,Anne Doersch,Gabriel Braley,Ralitza Gueorguieva,Thomas B. Cooper,Thomas B. Cooper,John H. Krystal +10 more
TL;DR: Delta-9-tetrahydrocannabinol is associated with transient exacerbation in core psychotic and cognitive deficits in schizophrenia, and this data do not provide a reason to explain why schizophrenia patients use or misuse cannabis.
Journal ArticleDOI
Hippocampal GABAergic Inhibitory Interneurons.
Kenneth A. Pelkey,Ramesh Chittajallu,Michael T. Craig,Ludovic Tricoire,Ludovic Tricoire,Jason C. Wester,Jason C. Wester,Chris J. McBain,Chris J. McBain +8 more
TL;DR: An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.
Journal ArticleDOI
The pattern of neurodegeneration in huntington's disease : A comparative study of cannabinoid, dopamine, adenosine and GABAA receptor alterations in the human basal ganglia in Huntington's disease
TL;DR: The finding that cannabinoid receptors are dramatically reduced in all regions of the basal ganglia in advance of other receptor changes in Huntington's disease suggests a possible role for cannabinoids in the progression of neurodegeneration in Huntington't disease.
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