Cardiolipin and mitochondrial cristae organization.
Nikita Ikon,Robert O. Ryan +1 more
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TLDR
Reconciling ultrastructural data with the lipid composition of the IM provides support for a continuously curved cylindrical bilayer capped by a dome-shaped tip, which has a direct impact on oxidative phosphorylation, apoptosis, fusion/fission as well as diseases of compromised energy metabolism.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2017-06-01 and is currently open access. It has received 197 citations till now. The article focuses on the topics: Inner mitochondrial membrane & Cardiolipin.read more
Citations
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Cardiomyocyte Maturation: New Phase in Development.
Yuxuan Guo,William T. Pu +1 more
TL;DR: The major hallmarks of ventricular cardiomyocyte maturation are reviewed and key regulatory mechanisms that promote and coordinate these cellular events are summarized.
Journal ArticleDOI
Emerging Diversity in Lipid–Protein Interactions
Valentina Corradi,Besian I. Sejdiu,Haydee Mesa-Galloso,Haleh Abdizadeh,Sergei Y. Noskov,Siewert J. Marrink,D. Peter Tieleman +6 more
TL;DR: Overall, a complex picture of lipid–protein interactions emerges, through a range of mechanisms including modulation of the physical properties of the lipid environment, detailed chemical interactions between lipids and proteins, and key functional roles of very specific lipids binding to well-defined binding sites on proteins.
Journal ArticleDOI
Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease
TL;DR: How reduced levels of Drp1, Aβ, and P-Tau can enhance the clearance of damaged mitochondria and other cellular debris by autophagy and mitophagy mechanisms is discussed.
Journal ArticleDOI
Role of Cardiolipin in Mitochondrial Function and Dynamics in Health and Disease: Molecular and Pharmacological Aspects.
TL;DR: The role played by CL in mitochondrial function and dynamics in health and diseases and on the potential of pharmacological modulation of CL through several agents in attenuating mitochondrial dysfunction are focused on.
Journal ArticleDOI
Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance.
TL;DR: This review discusses the current state-of-the-art of biomembrane simulations that, until now, have largely focused on a rather narrow picture of the complexity of the membranes, and discusses the challenges that should unravel in the foreseeable future.
References
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Journal ArticleDOI
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Christian Frezza,Sara Cipolat,Olga Martins de Brito,Massimo Micaroni,Galina V. Beznoussenko,Tomasz Rudka,Davide Bartoli,Roman S. Polishuck,Nika N. Danial,Bart De Strooper,Luca Scorrano +10 more
TL;DR: Evidence is provided that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion.
Journal ArticleDOI
Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health
TL;DR: By enabling content mixing between mitochondria, fusion and fission serve to maintain a homogeneous and healthy mitochondrial population and lead to improvements in human health.
Journal ArticleDOI
Lipids of mitochondria
TL;DR: The lipid content and lipid composition of mitochondria, a comparison between mitochondrial and other cellular membranes, and mitocbondria from microorganisms are compared.
Journal ArticleDOI
ULTRASTRUCTURAL BASES FOR METABOLICALLY LINKED MECHANICAL ACTIVITY IN MITOCHONDRIA I. Reversible Ultrastructural Changes with Change in Metabolic Steady State in Isolated Liver Mitochondria
TL;DR: Isolated mitochondria were found to oscillate between the orthodox and condensed conformations during reversible transitions between State III and State IV, representing an ultrastructural basis for metabolically linked mechanical activity in tightly coupled mitochondria.
Book
Fundamentals of Biochemistry
TL;DR: The foundations of biochemistry are studied in detail in order to establish a clear picture of the role of x-ray diffraction and Hamilton's inequality.
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