Cell alignment induced by anisotropic electrospun fibrous scaffolds alone has limited effect on cardiomyocyte maturation.
Jingjia Han,Qingling Wu,Younan Xia,Mary B. Wagner,Mary B. Wagner,Chunhui Xu,Chunhui Xu,Chunhui Xu +7 more
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TLDR
The results suggest that electrospun anisotropic fibrous scaffolds, as a single method, have limited effect on improving the maturation of hPSC-CMs.About:
This article is published in Stem Cell Research.The article was published on 2016-05-01 and is currently open access. It has received 72 citations till now.read more
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Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications
TL;DR: This work aims to provide a comprehensive overview of electrospun nanofibers, including the principle, methods, materials, and applications, and highlights the most relevant and recent advances related to the applications by focusing on the most representative examples.
Journal ArticleDOI
Electrospun Nanofibers: New Concepts, Materials, and Applications
TL;DR: The unique capabilities of electrospun nanofibers as porous supports for heterogeneous catalysis and as functional scaffolds for tissue regeneration are demonstrated by concentrating on some of the recent results.
Journal ArticleDOI
Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication.
TL;DR: The fundamental principles of electrospinning processes for generating complex fibrous scaffold geometries that are similar in structural complexity to the ECM of living tissues are summarized.
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Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium
Junjun Li,Itsunari Minami,Motoko Shiozaki,Leqian Yu,Shin Yajima,Shigeru Miyagawa,Yuji Shiba,Nobuhiro Morone,Satsuki Fukushima,Momoko Yoshioka,Sisi Li,Jing Qiao,X. Li,Lin Wang,Hidetoshi Kotera,Norio Nakatsuji,Yoshiki Sawa,Yong Chen,Yong Chen,Li Liu +19 more
TL;DR: A handy framework for cardiac tissue engineering is established by cultivating hiPSC-CMs on low-thickness aligned nanofibers made of biodegradable poly(D,L-lactic-co-glycolic acid) polymer, resulting in upregulated cardiac biomarkers and enhanced cardiac functions.
Journal ArticleDOI
Electrospun nanofibers promote wound healing: theories, techniques, and perspectives
Chen Gao,Liyuan Zhang,Juan Wang,Miao Jin,Qianqian Tang,Zhongrong Chen,Yue Cheng,Runhuai Yang,Gang Zhao +8 more
TL;DR: In this article, the authors provide a systematic review on recent researches on how electrospun nanofiber scaffolds promote wound healing and how the electrospinning technology has been used for fabricating multi-dimensional, multi-pore and multi-functional scaffolds that have greatly promoted the development of wound healing dressings.
References
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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,Maxim A. Vodyanik,Kim Smuga-Otto,Jessica Antosiewicz-Bourget,Jennifer L. Frane,Shulan Tian,Jeff Nie,Gudrun A. Jonsdottir,Victor Ruotti,Ron Stewart,Igor I. Slukvin,James A. Thomson +11 more
TL;DR: This article showed that OCT4, SOX2, NANOG, and LIN28 factors are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells.
Supporting Online Material for Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,Maxim A. Vodyanik,Kim Smuga-Otto,Jessica Antosiewicz-Bourget,Jennifer L. Frane,Shulan Tian,Jeff Nie,Gudrun A. Jonsdottir,Victor Ruotti,Ron M. Stewart,Igor I. Slukvin,James A. Thomson +11 more
TL;DR: Yu et al. as discussed by the authors proposed online material for induced pluripotent stem cell lines derived from human Somatic Cells, which can be used for transplanting human stem cells to humans.
Journal ArticleDOI
Electrospun nanofibrous structure: A novel scaffold for tissue engineering
TL;DR: A novel poly(D,L-lactide-co-glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue-engineering applications, which acts to support and guide cell growth.
Journal ArticleDOI
Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts
Michael A. Laflamme,Kent Chen,Anna V. Naumova,Veronica Muskheli,James A. Fugate,Sarah K. Dupras,Hans Reinecke,Chunhui Xu,Mohammad Hassanipour,Chris O'Sullivan,Lila R. Collins,Yinhong Chen,Elina Minami,Edward A. Gill,Shuichi Ueno,Chun Yuan,Joseph K. Gold,Charles E. Murry +17 more
TL;DR: This work generated highly purified human cardiomyocytes using a readily scalable system for directed differentiation that relies on activin A and BMP4, and identified a cocktail of pro-survival factors that limitsCardiomyocyte death after transplantation.
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Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
Xiaojun Lian,Cheston Hsiao,Gisela F. Wilson,Kexian Zhu,Laurie B. Hazeltine,Samira M. Azarin,Kunil K. Raval,Kunil K. Raval,Jianhua Zhang,Jianhua Zhang,Timothy J. Kamp,Timothy J. Kamp,Sean P. Palecek +12 more
TL;DR: It is shown that temporal modulation of Wnt signaling is both essential and sufficient for efficient cardiac induction in hPSCs under defined, growth factor-free conditions.