Journal ArticleDOI
Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics.
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TLDR
CCMCNCs comprise active cancer cell surface adhesive molecules combined with other functional proteins, and offer extended blood circulation with robust cell-specific targeting, ensuring enhanced intratumoral penetration and higher tumor-specific accumulation of NCs.About:
This article is published in Drug Discovery Today.The article was published on 2018-04-01. It has received 110 citations till now. The article focuses on the topics: Nanocarriers.read more
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Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application.
TL;DR: In this review, the biomimetic platform of erythrocyte membrane-coated nano-cores is described with regard to various aspects, with particular focus placed on the coating mechanism, preparation methods, verification methods, and the latest anti-tumor applications.
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Nanomaterial-based blood-brain-barrier (BBB) crossing strategies
TL;DR: This review summarizes the current understanding of the physiological structure of BBB, and provides various nanomaterial-based BBB-crossing strategies for brain delivery of theranostic agents.
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Supramolecular cancer nanotheranostics
TL;DR: In this paper, the authors summarized the progress of supramolecular cancer nanotheranostics and provided guidance for designing new targeted theranostic agents based on extensive state-of-the-art research.
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Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications
TL;DR: This review provides a comprehensive overview of the theory of cell membrane coating technology, followed by a summary of the existing preparation and characterization techniques, and focuses on the functions and applications of various cell membrane types.
Journal ArticleDOI
Tumor Cell-Derived Extracellular Vesicle-Coated Nanocarriers: An Efficient Theranostic Platform for the Cancer-Specific Delivery of Anti-miR-21 and Imaging Agents
Rajendran J.C. Bose,Sukumar Uday Kumar,Yitian Zeng,Rayhaneh Afjei,Elise Robinson,Kenneth K. S. Lau,Abel Bermudez,Frezghi Habte,Sharon J. Pitteri,Robert Sinclair,Juergen K. Willmann,Tarik F. Massoud,Sanjiv S. Gambhir,Ramasamy Paulmurugan +13 more
TL;DR: TEV-mediated anti-miR-21 delivery attenuated doxorubicin resistance in breast cancer cells with a 3-fold higher cell kill efficiency than in cells treated with DOX alone and TEVs and TEV-GIONs are promising nanotheranostics for future applications in cancer molecular imaging and therapy.
References
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Journal ArticleDOI
Cancer treatment and survivorship statistics, 2016.
Kimberly D. Miller,Rebecca L. Siegel,Chun Chieh Lin,Angela B. Mariotto,Joan L. Kramer,Julia H. Rowland,Kevin Stein,Rick Alteri,Ahmedin Jemal +8 more
TL;DR: The number of cancer survivors continues to increase because of both advances in early detection and treatment and the aging and growth of the population and for the public health community to better serve these survivors, the American Cancer Society and the National Cancer Institute collaborate to estimate the number of current and future cancer survivors.
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TL;DR: It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.
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Cancer nanomedicine: progress, challenges and opportunities.
TL;DR: Novel engineering approaches are discussed that capitalize on the growing understanding of tumour biology and nano–bio interactions to develop more effective nanotherapeutics for cancer patients.
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Analysis of nanoparticle delivery to tumours
Stefan Wilhelm,Anthony J. Tavares,Qin Dai,Seiichi Ohta,Seiichi Ohta,Julie Audet,Harold F. Dvorak,Warren C. W. Chan +7 more
TL;DR: This Perspective explores and explains the fundamental dogma of nanoparticle delivery to tumours and answers two central questions: ‘ how many nanoparticles accumulate in a tumour?’ and ‘how does this number affect the clinical translation of nanomedicines?'
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Tumor Metastasis: Molecular Insights and Evolving Paradigms
TL;DR: The invasion-metastasis cascade is a multistep cell-biological process that involves dissemination of cancer cells to anatomically distant organ sites and their subsequent adaptation to foreign tissue microenvironments as mentioned in this paper.