Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo
Abdelilah Wakkach,Nathalie Fournier,Valérie Brun,Jean-Philippe Breittmayer,Françoise Cottrez,Hervé Groux +5 more
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TLDR
In vitro culture of bone marrow cells in the presence of IL-10 induces the differentiation of a distinct subset of dendritic cells with a specific expression of CD45RB, identifying a natural DC subset that induces the differentiate of Tr1 cells in vitro and in vivo.About:
This article is published in Immunity.The article was published on 2003-05-01 and is currently open access. It has received 842 citations till now. The article focuses on the topics: Follicular dendritic cells & Antigen-presenting cell.read more
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IDO expression by dendritic cells: tolerance and tryptophan catabolism.
Andrew L. Mellor,David H. Munn +1 more
TL;DR: This review summarizes key recent developments and proposes a unifying model for the role of IDO in tolerance induction, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases.
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Regulatory T cells, tumour immunity and immunotherapy
TL;DR: The nature and characteristics of regulatory T cells in the tumour microenvironment and their potential multiple suppressive mechanisms are considered.
Journal ArticleDOI
Immunosuppressive Strategies that are Mediated by Tumor Cells
TL;DR: Different strategies employed by tumors to thwart immune responses, including tumor-induced impairment of antigen presentation, the activation of negative costimulatory signals, and the elaboration of immunosuppressive factors are discussed.
Journal ArticleDOI
Cytokines in atherosclerosis: pathogenic and regulatory pathways.
Alain Tedgui,Ziad Mallat +1 more
TL;DR: Based on the current knowledge of the role of cytokines in atherosclerosis, some novel therapeutic strategies to combat this disease are proposed and the potential of circulating cytokine levels as biomarkers of coronary artery disease is discussed.
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Th17: an effector CD4 T cell lineage with regulatory T cell ties.
TL;DR: Th17 lineage development is reviewed, emphasizing similarities and differences with established effector and regulatory T cell developmental programs that have important implications for immune regulation, immune pathogenesis, and host defense.
References
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Dendritic cells and the control of immunity
TL;DR: Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis and the realization that these cells are a powerful tool for manipulating the immune system is realized.
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Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
K Inaba,M Inaba,Nikolaus Romani,H Aya,Masashi Deguchi,Susumu Ikehara,Shigeru Muramatsu,Ralph M. Steinman +7 more
TL;DR: The methodology for inducing dendritic cell growth that was recently described for mouse blood now has been modified to MHC class II- negative precursors in marrow, and this feature should prove useful for future molecular and clinical studies of this otherwise trace cell type.
Journal ArticleDOI
A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
Hervé Groux,Anne O'Garra,M. Bigler,Matthieu Rouleau,Svetlana Antonenko,Jan E. de Vries,Maria Grazia Roncarolo +6 more
TL;DR: It is shown that chronic activation of both human and murine CD4+T cells in the presence of interleukin (IL)-10 gives rise to CD4-T-cell clones with low proliferative capacity, producing high levels ofIL-10, low levels of IL-2 and no IL-4.
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Mouse and human dendritic cell subtypes
Ken Shortman,Yong-Jun Liu +1 more
TL;DR: The dynamics of the DC network in response to microbial invasion is studied, because many DC subtypes arise from separate developmental pathways, and their development and function are modulated by exogenous factors.
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Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Marie-Clotilde Rissoan,Vassili Soumelis,Norimitsu Kadowaki,Géraldine Grouard,Francine Brière,Rene de Waal Malefyt,Yong-Jun Liu +6 more
TL;DR: A negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.