Child–Parent Familial Hypercholesterolemia Screening in Primary Care
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TLDR
Child-parent screening was feasible in primary care practices at routine child immunization visits and 8 persons were identified as having positive screening results for familial hypercholesterolemia and were consequently at high risk for cardiovascular disease.Abstract:
BackgroundChild–parent screening for familial hypercholesterolemia has been proposed to identify persons at high risk for inherited premature cardiovascular disease. We assessed the efficacy and feasibility of such screening in primary care practice. MethodsWe obtained capillary blood samples to measure cholesterol levels and to test for familial hypercholesterolemia mutations in 10,095 children 1 to 2 years of age during routine immunization visits. Children were considered to have positive screening results for familial hypercholesterolemia if their cholesterol level was elevated and they had either a familial hypercholesterolemia mutation or a repeat elevated cholesterol level 3 months later. A parent of each child with a positive screening result for familial hypercholesterolemia was considered to have a positive screening result for familial hypercholesterolemia if he or she had the same mutation as the child or, if no mutations were identified, had the higher cholesterol level of the two parents. Re...read more
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Atherosclerotic Cardiovascular Risk as an Emerging Priority in Pediatrics.
TL;DR: The underlying advances in cardiovascular risk assessment and management are discussed, and disease-associated factors that add to the traditional risk factors are reviewed, including inflammation, vascular, and endothelial factors.
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Persistent High Non-High-Density Lipoprotein Cholesterol in Early Childhood: A Latent Class Growth Model Analysis.
Jordan M. Albaum,Sarah Carsley,Yang Chen,David Dai,Gerald Lebovic,Brian W. McCrindle,Jonathon L Maguire,Patricia C. Parkin,Catherine S Birken +8 more
TL;DR: Patterns of non‐ HDL cholesterol are identified during early childhood, and family history of high cholesterol was associated most strongly with persistent high non‐HDL cholesterol.
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Improving detection and management of familial hypercholesterolaemia in Australian general practice
Tom Brett,Dick C. Chan,Jan Radford,Clare Heal,Gerard Gill,Charlotte Hespe,Cristian Vargas-Garcia,Carmen Condon,Barbara Sheil,Ian Li,David R. Sullivan,Alistair Vickery,Jing Pang,Diane Arnold-Reed,Gerald F. Watts,Gerald F. Watts +15 more
TL;DR: In this article, a two-stage pragmatic approach was employed to identify and manage patients with familial hypercholesterolaemia (FH) in primary healthcare, which is characterised by elevated low-density lipoprotein (LDL)-cholesterol and increased risk of cardiovascular disease.
Journal ArticleDOI
Past, Present, and Future of Familial Hypercholesterolemia Management
Viviane Z. Rocha,Raul D. Santos +1 more
TL;DR: While it is possible to normalize LDL-C in people with FH, the disease unfortunately is still severely underdiagnosed and undertreated.
Journal ArticleDOI
Familial Hypercholesterolemia in Asia Pacific: A Review of Epidemiology, Diagnosis, and Management in the Region.
Sanjay Kalra,Zhenyue Chen,Chaicharn Deerochanawong,Kou-Gi Shyu,Ru San Tan,Brian Tomlinson,Hung-I Yeh +6 more
TL;DR: A literature review of the epidemiology, diagnosis, and management of familial hypercholesterolemia (FH) across the Asia-pacific region is presented in this article, which concludes with a Call to Action on FH for Asia Pacific to engage healthcare professionals, improve public awareness, and form national FH alliances, comprising all relevant healthcare professional organizations.
References
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Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society
Børge G. Nordestgaard,M. John Chapman,Steve E. Humphries,Henry N. Ginsberg,Luis Masana,Olivier S. Descamps,Olov Wiklund,Robert A. Hegele,Frederick J. Raal,Joep C. Defesche,Albert Wiegman,Raul D. Santos,Gerald F. Watts,Klaus G. Parhofer,G. Kees Hovingh,Petri T. Kovanen,Catherine Boileau,Maurizio Averna,Jan Borén,Eric Bruckert,Alberico L. Catapano,Jan Albert Kuivenhoven,Jan Albert Kuivenhoven,P. Pajukanta,Kausik K. Ray,Anton F. H. Stalenhoef,Erik S.G. Stroes,Marja-Riitta Taskinen,Anne Tybjærg-Hansen +28 more
TL;DR: There is an urgent worldwide need for diagnostic screening together with early and aggressive treatment of this extremely high-risk condition, familial hypercholesterolaemia.
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First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS).
TL;DR: The matching criteria were gestation (using an ultrasound crown–rump length or biparietal diameter measurement), duration of storage, and centre, and Screening performance of the individual markers and combinations of markers together with maternal age was assessed.
Journal ArticleDOI
Efficacy and safety of statin therapy in Children with familial hypercholesterolemia: A randomized controlled trial
Albert Wiegman,Barbara A. Hutten,Eric de Groot,Jessica Rodenburg,Henk D. Bakker,Harry R. Büller,Eric J.G. Sijbrands,John J.P. Kastelein +7 more
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Familial Hypercholesterolemia in the Danish General Population: Prevalence, Coronary Artery Disease, and Cholesterol-Lowering Medication
Marianne Benn,Gerald F. Watts,Anne Tybjærg-Hansen,Børge G. Nordestgaard,Børge G. Nordestgaard +4 more
TL;DR: The prevalence of familial hypercholesterolemia appears to be higher than commonly perceived in a general population of white Danish individuals, with at least half of affected subjects not receiving cholesterol-lowering medication.
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