Circ2Traits: a comprehensive database for circular RNA potentially associated with disease and traits.
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TLDR
The interactions of circRNAs with disease associated miRNAs were identified, following which the likelihood of a circRNA being associated with a disease was calculated and a database of disease-circRNA association in Circ2Traits, the first comprehensive knowledgebase of potential association of circular RNAs with diseases in human.Abstract:
Circular RNAs are new players in regulation of post transcriptional gene expression. Animal genomes express many circular RNAs from diverse genomic locations. A recent study has validated a fairly large number of circular RNAs in human, mouse and nematode. Circular RNAs play a crucial role in fine tuning the level of miRNA mediated regulation of gene expression by sequestering the miRNAs. Their interaction with disease associated miRNAs indicates that circular RNAs are important for disease regulation. We studied the potential association of circular RNAs (circRNA) with human diseases in two different ways. First, the interactions of circRNAs with disease associated miRNAs were identified, following which the likelihood of a circRNA being associated with a disease was calculated. For the miRNAs associated with individual diseases, we constructed a network of predicted interactions between the miRNAs and protein coding, long noncoding and circular RNA genes. We carried out gene ontology (GO) enrichment analysis on the set of protein coding genes in the miRNA- circRNA interactome of individual diseases to check the enrichment of genes associated with particular biological processes. Second, disease associated SNPs were mapped on circRNA loci, and Argonaute (Ago) interaction sites on circular RNAs were identified. We compiled a database of disease-circRNA association in Circ2Traits ( http://gyanxet-beta.com/circdb/ ), the first comprehensive knowledgebase of potential association of circular RNAs with diseases in human.read more
Citations
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Journal ArticleDOI
Circular RNA: A new star of noncoding RNAs
Shibin Qu,Xisheng Yang,Xiaolei Li,Jianlin Wang,Yuan Gao,Runze Shang,Wei Sun,Kefeng Dou,Haimin Li +8 more
TL;DR: Similar to miRNAs and long noncoding RNAs (lncRNAs), circRNAs are becoming a new research hotspot in the field of RNA and could be widely involved in the processes of life.
Journal ArticleDOI
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches
TL;DR: This review guides the reader through important aspects of non-coding RNA biology, including their biogenesis, mode of actions, physiological function, as well as their role in the disease context (such as in cancer or the cardiovascular system).
Book ChapterDOI
Circular RNAs Act as miRNA Sponges.
TL;DR: Current knowledge of the miRNA-circRNA interaction and mechanisms that influence gene expression are summarized.
Journal ArticleDOI
Using circular RNA as a novel type of biomarker in the screening of gastric cancer
Peifei Li,Shengcan Chen,Huilin Chen,Xiaoyan Mo,Tianwen Li,Yongfu Shao,Bingxiu Xiao,Junming Guo +7 more
TL;DR: It is suggested that circRNAs are highly stable in mammalian cells and that one specific circRNA, hsa_circ_002059, may be a potential novel and stable biomarker for the diagnosis of gastric carcinoma.
Journal ArticleDOI
Circular RNAs are miRNA sponges and can be used as a new class of biomarker.
TL;DR: The biogenesis, properties and function of endogenous circRNA sponges, with a special focus on those related to human cancer, are reviewed and the possibility of using circRNAs as molecular markers for the diagnosis of diseases is discussed.
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