Open AccessJournal Article
Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271.
TLDR
Results identified a new functional circ-ABCB10 in breast cancer tumorigenesis, and reveal the important regulatory role of circ- ABCB10 through sponging miR-1271, providing a novel insight for breast cancer pathogenesis.Abstract:
Circular RNA (circRNA) is a key regulator in the development and progression of human cancers, however its role in breast cancer tumorigenesis is not well understood. The present study aims to investigate the expression profiles and potential modulation of circRNA on breast cancer carcinogenesis. Human circRNA microarray was performed to screen for abnormally expressed circRNA in breast cancer tissue. Results found circ-ABCB10, was significantly up-regulated in breast cancer tissue. And results were replicated in a larger sample size. In vitro, loss-of-function experiments showed circ-ABCB10 knockdown suppressed the proliferation and increased apoptosis of breast cancer cells. Bioinformatics prediction program predicted the complementary sequence within circ-ABCB10 and miR-1271, which was validated by luciferase reporter assay. Finally, miR-1271 rescued the function of circ-ABCB10 on breast cancer cells, confirming the sponge effect of circ-ABCB10 on miR-1271. Overall, results identified a new functional circ-ABCB10 in breast cancer tumorigenesis, and reveal the important regulatory role of circ-ABCB10 through sponging miR-1271, providing a novel insight for breast cancer pathogenesis.read more
Citations
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Circular RNAs in cancer: opportunities and challenges in the field.
TL;DR: The current knowledge on circRNAs is reviewed in relation to their implications in tumorigenesis as well as their potential as diagnostic and prognostic biomarkers and as possible therapeutic targets in future personalized medicine.
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Circular RNAs Act as miRNA Sponges.
TL;DR: Current knowledge of the miRNA-circRNA interaction and mechanisms that influence gene expression are summarized.
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Circular RNA and its mechanisms in disease: From the bench to the clinic.
Bing Han,Jie Chao,Honghong Yao +2 more
TL;DR: Although their exact roles and mechanisms of gene regulation remain to be clarified, circRNAs have potential applications as disease biomarkers and novel therapeutic targets.
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circRNAs in Cancer
TL;DR: This review describes general advances in the field regarding circRNA biogenesis and functions in relationship with cancer and summarizes some necessary precautions to work with circRNAs that are particularly relevant to cancer-related studies.
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Circular RNAs in Cancer
TL;DR: The characteristics, functions, and mechanisms of action of circRNAs in cancer are highlighted and an overview of recent progress in the circRNA field is provided and future application of circ RNAs as cancer biomarkers and novel therapeutic targets is provided.
References
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Journal ArticleDOI
CircRNA: functions and properties of a novel potential biomarker for cancer
Meng Shujuan,Meng Shujuan,Zhou Hecheng,Zhou Hecheng,Feng Ziyang,Feng Ziyang,Xu Zihao,Xu Zihao,Tang Ying,Tang Ying,Peiyao Li,Minghua Wu +11 more
TL;DR: A review of recent research shows that circular RNAs may function as potential molecular markers for disease diagnosis and treatment and play an important role in the initiation and progression of human diseases, especially in tumours.
Journal ArticleDOI
Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression.
Dan Han,Jiangxue Li,Huamin Wang,Xiaoping Su,Jin Hou,Yan Gu,Cheng Qian,Yun Lin,Xiang Liu,Mingyan Huang,Nan Li,Weiping Zhou,Yizhi Yu,Xuetao Cao +13 more
TL;DR: In this article, the expression profile and function of circRNAs in human hepatocellular carcinoma (HCC) remain to be investigated, and the authors used a biotin-labeled circMTO1 probe to perform RNA in vivo precipitation in HCC cells.
Journal ArticleDOI
The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells
Huanyu Xu,Sen Guo,Wei Li,Ping Yu +3 more
TL;DR: The effects of the strongly interacting pair of Cdr1as/miR-7 on insulin secretion, which may become a new target for improving β cell function in diabetes, are revealed.
Journal ArticleDOI
Insights into circular RNA biology.
TL;DR: In this review, a brief introduction to the characteristics that define a circRNA will be given followed by a discussion of putative biogenesis pathways and modulators of circRNA expression as well as of the stage at which circRNA formation takes place.
Journal ArticleDOI
Circular RNAs in human cancer
Yumin Wang,Yongzhen Mo,Zhaojian Gong,Xiang Yang,Mo Yang,Shanshan Zhang,Fang Xiong,Bo Xiang,Ming Zhou,Qianjin Liao,Wenling Zhang,Xiayu Li,Xiaoling Li,Yong Li,Yong Li,Guiyuan Li,Zhaoyang Zeng,Wei Xiong +17 more
TL;DR: The role of circRNAs as molecular markers or potential targets will provide promising application perspectives, such as early tumor diagnosis, therapeutic evaluation, prognosis prediction, and even gene therapy for tumors.