Clearance of Apoptotic Cells: Getting Rid of the Corpses
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In this article, the authors present a simplified model of the phagocytic synapse and discuss the role of lysophosphatidylcholine as soluble attraction signal in the removal of apoptotic cells.About:
This article is published in Molecular Cell.The article was published on 2004-05-07 and is currently open access. It has received 568 citations till now. The article focuses on the topics: Apoptotic cell clearance & Tissue homeostasis.read more
Citations
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Calreticulin exposure dictates the immunogenicity of cancer cell death
Michel Obeid,Antoine Tesniere,Antoine Tesniere,Antoine Tesniere,François Ghiringhelli,François Ghiringhelli,François Ghiringhelli,Gian Maria Fimia,Lionel Apetoh,Lionel Apetoh,Lionel Apetoh,Jean-Luc Perfettini,Jean-Luc Perfettini,Jean-Luc Perfettini,Maria Castedo,Maria Castedo,Maria Castedo,Grégoire Mignot,Grégoire Mignot,Grégoire Mignot,Theoharis Panaretakis,Theoharis Panaretakis,Theoharis Panaretakis,Noelia Casares,Noelia Casares,Noelia Casares,Didier Métivier,Didier Métivier,Didier Métivier,Nathanael Larochette,Nathanael Larochette,Nathanael Larochette,Peter van Endert,Peter van Endert,Fabiola Ciccosanti,Mauro Piacentini,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Guido Kroemer,Guido Kroemer,Guido Kroemer +41 more
TL;DR: It is shown that anthracyclin-induced CRT translocation induces the rapid, preapoptotic translocation of calreticulin (CRT) to the cell surface and is identified as a key feature determining anticancer immune responses.
Journal ArticleDOI
Resolution of inflammation: the beginning programs the end.
Charles N. Serhan,John Savill +1 more
TL;DR: Emerging evidence now suggests that an active, coordinated program of resolution initiates in the first few hours after an inflammatory response begins, and the mechanism required for inflammation resolution may underpin the development of drugs that can resolve inflammatory processes in directed and controlled ways.
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Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Michael R. Elliott,Faraaz B. Chekeni,Paul C. Trampont,Eduardo R. Lazarowski,Alexandra Kadl,Scott F. Walk,Daeho Park,Robin I. Woodson,Marina Ostankovich,Poonam Sharma,Jeffrey J. Lysiak,T. Kendall Harden,Norbert Leitinger,Kodi S. Ravichandran,Kodi S. Ravichandran +14 more
TL;DR: Nucleotides are identified as a critical find-me cue released by apoptotic cells to promote P2Y2-dependent recruitment of phagocytes, and provide evidence for a clear relationship between a find- me signal and efficient corpse clearance in vivo.
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Overview of cell death signaling pathways
Zhaoyu Jin,Wafik S. El-Deiry +1 more
TL;DR: Changing attention is being focused on alternative signaling pathways leading to cell death including necrosis, autophagy, and mitotic catastrophe.
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Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death.
Noelia Casares,Marie O. Pequignot,Antoine Tesniere,François Ghiringhelli,Stephan Roux,Nathalie Chaput,Elise Schmitt,Ahmed Hamaï,Sandra Hervas-Stubbs,Michel Obeid,Fréderic Philippe Coutant,Didier Métivier,Evelyne Pichard,Pierre Aucouturier,Gérard Pierron,Carmen Garrido,Laurence Zitvogel,Guido Kroemer +17 more
TL;DR: It is shown that even in the absence of any adjuvant, tumor cells dying in response to anthracyclins can elicit an effective antitumor immune response that suppresses the growth of inoculated tumors or leads to the regression of established neoplasia.
References
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Journal Article
Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.
Valerie A. Fadok,Dennis R. Voelker,Priscilla A. Campbell,J. John Cohen,D L Bratton,Peter M. Henson +5 more
TL;DR: The data suggest that macrophages specifically recognize phosphatidylserine that is exposed on the surface of lymphocytes during the development of apoptosis, and suggest that apoptotic lymphocytes lose membrane phospholipid asymmetry and expose phosphorus on the outer leaflet of the plasma membrane.
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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.
TL;DR: The results suggest that binding and/or phagocytosis of apoptotic cells induces active antiinflammatory or suppressive properties in human macrophages, likely that resolution of inflammation depends not only on the removal of apoptosis but on active suppression of inflammatory mediator production.
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Immunosuppressive effects of apoptotic cells
Reinhard E. Voll,Martin Herrmann,Edith Roth,Christian Stach,Joachim R. Kalden,Irute Girkontaite +5 more
TL;DR: The presence of apoptotic cells during monocyte activation increases their secretion of the anti-inflammatory and immunoregulatory cytokine interleukin 10 (IL-10) and decreases secretion ofthe proinflammatory cytokines tumour necrosis factor-α (TNF-α), IL-1 and IL-12, which may inhibit inflammation and contribute to impaired cell-mediated immunity in conditions associated with increased apoptosis.
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Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.
TL;DR: Systemic lupus erythematosus is a multisystem autoimmune disease in which the autoantibody response targets a variety of autoantigens of diverse subcellular location, and it is shown that they are clustered in two distinct populations of blebs at the surface of apoptotic cells.
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A receptor for phosphatidylserine-specific clearance of apoptotic cells
Valerie A. Fadok,Donna L. Bratton,David M. Rose,Alan Pearson,R. Alan B. Ezekewitz,Peter M. Henson +5 more
TL;DR: Using phage display, a gene that appears to recognize phosphatidylserine on apoptotic cells is cloned and shown to be highly homologous to genes of unknown function in Caenorhabditis elegans and Drosophila melanogaster, suggesting that phosphatido-serine recognition on apoptosis cells during their removal by phagocytes is highly conserved throughout phylogeny.