Clinical Study of Mesenchymal Stem Cell Treatment for Acute Respiratory Distress Syndrome Induced by Epidemic Influenza A (H7N9) Infection: A Hint for COVID-19 Treatment
Jiajia Chen,Chenxia Hu,Lijun Chen,Lingling Tang,Yixin Zhu,Xiaowei Xu,Lu Chen,Hainv Gao,Xiaoqing Lu,Liang Yu,Xiahong Dai,Charlie Xiang,Lanjuan Li +12 more
TLDR
It is suggested that MSCs significantly improve the survival rate of H7N9-induced ARDS and provide a theoretical basis for the treatment of H6N9 and the corona virus disease 2019 (COVID-19) in both preclinical research and clinical studies.About:
This article is published in Engineering.The article was published on 2020-02-28 and is currently open access. It has received 218 citations till now. The article focuses on the topics: ARDS & Transplantation.read more
Citations
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The cytokine storm and COVID-19.
TL;DR: The current understanding of the features of SARS‐CoV‐2 and the pathological features, pathophysiological mechanisms, and treatments of the cytokine storm induced by COVID‐19 are reviewed and it is suggested that the identification and treatment of theocyte storm are important components for rescuing patients with severe CO VID‐19.
Journal ArticleDOI
COVID-19: immunopathogenesis and Immunotherapeutics.
TL;DR: The immunopathology of COVID-19 is discussed, its potential mechanisms, and clinical implications to aid the development of new therapeutic strategies against COIDs, which includes enhancing anti-viral immunity while inhibiting systemic inflammation.
Journal ArticleDOI
Mesenchymal Stem Cell Therapy for COVID-19: Present or Future.
TL;DR: This study considered this new approach to improve patient’s immunological responses to COVID-19 using MSCs and discussed the aspects of this proposed treatment.
Journal ArticleDOI
Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial.
Giacomo Lanzoni,E. Linetsky,Diego Correa,Shari Messinger Cayetano,Roger A. Alvarez,Dimitrios Kouroupis,Ana M. Alvarez Gil,Raffaella Poggioli,Phillip Ruiz,Antonio Marttos,Khemraj Hirani,Crystal A. Bell,Halina Kusack,Lisa E. Rafkin,David A. Baidal,Andrew Pastewski,Kunal Gawri,Clarissa Leñero,Alejandro Mantero,Sarah W. Metalonis,Xiaojing Wang,Luis Roque,Burlett Masters,Norma S. Kenyon,Enrique Ginzburg,Xiumin Xu,Jianming Tan,Arnold I. Caplan,Marilyn K. Glassberg,Rodolfo Alejandro,Camillo Ricordi +30 more
TL;DR: In this article, a double-blind, phase 1/2a, randomized, controlled trial was performed to determine safety and explore efficacy of umbilical cord mesenchymal stem cell (UC-MSC) infusions in subjects with COVID-19 ARDS.
Journal ArticleDOI
COVID-19 vaccines: The status and perspectives in delivery points of view.
TL;DR: In this paper, the virology and immunology of SARS-CoV-2, alternative therapies for COVID-19 to vaccination, principles and design considerations in vaccine development, and the promises and roles of vaccine carriers in addressing the unique immunopathological challenges presented by the disease.
References
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TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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