Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.About:
This article is published in Pharmacological Research.The article was published on 2005-10-01. It has received 1573 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
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Synthesis and evaluation of new 1,2,4-oxadiazole based trans- acrylic acid derivatives as potential PPAR-alpha/gamma dual agonist
Paranjeet Kaur,Zahid Rafiq Bhat,Sana Shafi Bhat,Rakesh Kumar,Rajan Kumar,Kulbhushan Tikoo,Jeena Gupta,Navneet Khurana,Jaskiran Kaur,Gopal L. Khatik +9 more
TL;DR: Trans- acrylic acid derivatives can be further developed as oral therapeutic agents for diabetic interventions as PPAR alpha/gamma dual agonists as well as in-silico toxicity and in- silico ADME properties.
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Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress.
Jia-Hui Tian,Qian Wu,Yong-Xiang He,Qi-ying Shen,Mubarak Rekep,Gui-Ping Zhang,Jiandong Luo,Qin Xue,Yinghua Liu +8 more
TL;DR: The findings suggest that ZNS improves the cardiac diastolic function in diabetic mice and prevents T2DM-induced cardiac hypertrophy by attenuating ER stress-mediated apoptosis.
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Protective effect of gymnema sylvestre ethanol extract on high fat diet-induced obese diabetic wistar rats
TL;DR: Oral treatment with water soluble fraction of Gymnema sylvestre ethanol extract resulted in significant reduction in heart rate, mean arterial pressure, serum leptin, insulin, apolipoprotein B, lipids, glucose, cardiac caspase-3 levels, Na+/K+ ATPase activity and DNA laddering, visceral fat pad and organ's weight and improved the antioxidant enzymes levels in the high fat diet induced obesity in diabetic rats.
Journal Article
Effect of riceberry oil (deep purple oil; Oryza sativa Indica) supplementation on hyperglycemia and change in lipid profile in streptozotocin (STZ)-induced diabetic rats fed a high fat diet.
Ratchanee Kongkachuichai,Pattaneeya Prangthip,R. Surasiang,J. Posuwan,Rin Charoensiri,Aikkarach Kettawan,Apichart Vanavichit +6 more
TL;DR: Findings in the present study demonstrate that RBBO, a nutraceutical food, may be useful as an alternative food supplement for the alleviation of hyperglycemia and dyslipidemia conditions.
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Detrusor contractility to parasympathetic mediators is differentially altered in the compensated and decompensated states of diabetic bladder dysfunction.
TL;DR: The data suggest that the compensated state of DBD progresses temporally into the decompensated state in the HFD/STZ male model of diabetes; therefore, this male HFD-STZ model can be used to study DBD progression.
References
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Journal ArticleDOI
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
TL;DR: How advances in the understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance is discussed.
Journal ArticleDOI
Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
TL;DR: Clinical studies in patients with type II diabetes, as well as other syndromes characterized by insulin resistance, have demonstrated that thiazolidinediones may represent a safe and effective new treatment.
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A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
M. J. Reed,K. Meszaros,L. J. Entes,M. D. Claypool,J. G. Pinkett,T.M Gadbois,Gerald M. Reaven +6 more
TL;DR: Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.