Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.About:
This article is published in Pharmacological Research.The article was published on 2005-10-01. It has received 1573 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
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Hippocampus kuda protein hydrolysate improves male reproductive dysfunction in diabetic rats.
TL;DR: In this paper, the peptide hydrolysate (SH) of seahorses was investigated for male reproductive dysfunction in rat models, and the in vivo studies were carried out with three different doses of SH (4, 8, and 20 ) and the diabetes condition was induced by administrating with streptozotocin (35 ) and fed a 40% high fat diet.
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Intervention of Gastrodin in Type 2 Diabetes Mellitus and Its Mechanism.
TL;DR: In this paper, the effects and possible mechanisms of gastrodin on the treatment of type 2 diabetes mellitus (T2DM) were investigated, and the results showed that Gastrodin upregulated the expression of insulin receptors and ubiquitin-specific protease 4 (USP4) and increased the phosphorylation of GATA binding protein 1 and protein kinase B (AKT) in vivo and in vitro.
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Evaluation of Hypoglycemic Effect of Achillea biebersteinii Afan., Growing in Syria, in Induced Diabetic Rats
TL;DR: In conclusion, A. biebersteinii Afan.
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Improvement of cognitive function, glucose and lipid homeostasis and serum osteocalcin levels by liraglutide in diabetic rats.
TL;DR: In this article, the effects of 4 weeks liraglutide treatment on changes in cognitive function and bone homeostasis, induced by high fat diet/low-dose streptozotocin (HFD-STZ), were determined in rats.
Journal ArticleDOI
Effect of Phytopreparations Based on Bioreactor-Grown Cell Biomass of Dioscorea deltoidea, Tribulus terrestris and Panax japonicus on Carbohydrate and Lipid Metabolism in Type 2 Diabetes Mellitus.
Maria N. Povydysh,M. V. Titova,I. M. Ivanov,Andrey G. Klushin,Dmitry V. Kochkin,Boris A. Galishev,Elena Popova,Dmitry Ivkin,Vladimir G. Luzhanin,M.V. Krasnova,Natalia V. Demakova,Alexander Nosov +11 more
TL;DR: This paper explored the therapeutic potential of bioreactor-grown cell cultures of the medicinal plant species Dioscorea deltoidea, Tribulus terrestris and Panax japonicus to treat carbohydrate metabolism disorders (CMDs) in laboratory rats.
References
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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
TL;DR: How advances in the understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance is discussed.
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Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
TL;DR: Clinical studies in patients with type II diabetes, as well as other syndromes characterized by insulin resistance, have demonstrated that thiazolidinediones may represent a safe and effective new treatment.
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A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
M. J. Reed,K. Meszaros,L. J. Entes,M. D. Claypool,J. G. Pinkett,T.M Gadbois,Gerald M. Reaven +6 more
TL;DR: Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.