Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.About:
This article is published in Pharmacological Research.The article was published on 2005-10-01. It has received 1573 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
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Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats.
Zhenwen Zhang,Penghua Fang,Biao He,Lili Guo,Johan Runesson,Ülo Langel,Mingyi Shi,Yan Zhu,Ping Bo +8 more
TL;DR: The results suggest that excitation of central galanin receptor 1 facilitates insulin sensitivity via activation of the Akt/AS160 signaling pathway in the fat cells of type 2 diabetic rats.
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Swimming exercise attenuates anxiety-like behavior by reducing brain oxidative stress in type 2 diabetic mice.
TL;DR: In this paper, the effects of swimming exercise on body weight, anxiety-like behavior, glucose and insulin levels, and brain oxidative stress in male C57BL/6 mice were investigated.
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GTF-231, a Mixture of Gymnemic Acid, Trigonelline and Ferulic Acid Significantly Ameliorates Oxidative Stress in Experimental Type 2 Diabetes in Rats.
TL;DR: The observed antioxidant potential of GTF-231 may account for its significant antidiabetic properties in rats with type 2 diabetes.
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Antidiabetic Effect of Tibetan Medicine Tang-Kang-Fu-San on High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Rats
Bailu Duan,Zhongqiu Zhao,Ling Lin,Jing Jin,Lijun Zhang,Hui Xiong,Na Ta,Tiexiang Gao,Zhinan Mei +8 more
TL;DR: It is shown that TKFS could alleviate diabetic syndromes, maintain the glucose homeostasis, and protect against insulin resistance in T2DM rats, and the improvement of AKT phosphorylation and GLUT4 translocation in skeletal muscle would be one of its possible underlying mechanisms.
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Jejunum-ileum circuit procedure improves glucose metabolism in diabetic rats independent of weight loss.
Yanmin Wang,Xiang Zhang,Teng Liu,Mingwei Zhong,Houmin Wan,Shaozhuang Liu,Guangyong Zhang,Ghassan S. Kassab,Sanyuan Hu +8 more
TL;DR: To introduce a lower‐risk novel surgical procedure to achieve diabetes reversal along with associated hormonal changes in women with type 2 diabetes.
References
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Journal ArticleDOI
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
TL;DR: How advances in the understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance is discussed.
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Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
TL;DR: Clinical studies in patients with type II diabetes, as well as other syndromes characterized by insulin resistance, have demonstrated that thiazolidinediones may represent a safe and effective new treatment.
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A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
M. J. Reed,K. Meszaros,L. J. Entes,M. D. Claypool,J. G. Pinkett,T.M Gadbois,Gerald M. Reaven +6 more
TL;DR: Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.