Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.About:
This article is published in Pharmacological Research.The article was published on 2005-10-01. It has received 1573 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
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Neuroprotective effect of epalrestat mediated through oxidative stress markers, cytokines and TAU protein levels in diabetic rats.
TL;DR: The findings suggest that diabetic rats treated with epalrestat could ameliorate the cognition deficits and might act as a beneficial agent for prevention and treatment of cognitive impairment in diabetes.
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Effect of dietary Acrocomia aculeata kernel oil rich in medium chain fatty acids on type 2 diabetic rats
Ângela Alves Nunes,Danieli Fernanda Buccini,Jeandre Augusto dos Santos Jaques,Luciane Candeloro Portugal,Rita de Cássia Avellaneda Guimarães,Simone Palma Favaro,Ruy de Araújo Caldas,Cristiano Marcelo Espinola Carvalho +7 more
TL;DR: Findings suggest AKO was effective to ameliorate the health of diabetic rats, as partial substitute of carbohydrate calories upon blood glucose, lipid profile, insulin secretion and insulin sensitivity.
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Inhibition of the hepatic glucose output is responsible for the hypoglycemic effect of Crataegus aronia against type 2 diabetes mellitus in rats
TL;DR: In conclusion, C. aronia ameliorates T2DM by inhibiting hepatic glucose output, responsible for the hypoglycemic effect of Crataegus aronia against type 2 diabetes mellitus in rats.
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L-ergothioneine and its combination with metformin attenuates renal dysfunction in type-2 diabetic rat model by activating Nrf2 antioxidant pathway.
TL;DR: In this paper, the effect of L-ergothioneine (L-egt) alone or combined with metformin on renal damage in a type-2 diabetic (T2D) rat model was investigated.
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Effect of maternal use of flaxseed oil during pregnancy and lactation on glucose metabolism and pancreas histomorphometry of male offspring from diabetic rats.
André Manoel Correia-Santos,Akemi Suzuki,Gabriela Câmara Vicente,Juliana Saraiva dos Anjos,Aline D'Avila Pereira,Kátia Calvi Lenzi-Almeida,Gilson Teles Boaventura +6 more
TL;DR: Flaxseed oil reduced the damage caused by maternal hyperglycemia, promoting normal pancreas histomorphometry and β cell mass, and prevented pancreatic alterations in the offspring of diabetic mothers.
References
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Journal ArticleDOI
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
TL;DR: How advances in the understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance is discussed.
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Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
TL;DR: Clinical studies in patients with type II diabetes, as well as other syndromes characterized by insulin resistance, have demonstrated that thiazolidinediones may represent a safe and effective new treatment.
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A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
M. J. Reed,K. Meszaros,L. J. Entes,M. D. Claypool,J. G. Pinkett,T.M Gadbois,Gerald M. Reaven +6 more
TL;DR: Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.