Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.About:
This article is published in Pharmacological Research.The article was published on 2005-10-01. It has received 1573 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
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In Vivo Rodent Models of Type 2 Diabetes and Their Usefulness for Evaluating Flavonoid Bioactivity
TL;DR: This review discusses the currently available rodent animal models of T2D and analyzes the advantages, the limitations, and the potential anti-diabetic effects of flavonoids as well as the mechanisms of their actions.
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A Review of Islet of Langerhans Degeneration in Rodent Models of Type 2 Diabetes
TL;DR: The importance, advantages, and limitations of rodent models of TTDM in relation to the histopathological changes that characterize islet degeneration are reviewed and placed into the context of changes in islet histological appearances.
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Multiple Low-Dose Radiation Prevents Type 2 Diabetes-Induced Renal Damage through Attenuation of Dyslipidemia and Insulin Resistance and Subsequent Renal Inflammation and Oxidative Stress
Minglong Shao,Xuemian Lu,Weitao Cong,Xiao Xing,Yi Tan,Yunqian Li,Xiaokun Li,Litai Jin,Xiaojie Wang,Juancong Dong,Shunzi Jin,Chi Zhang,Lu Cai +12 more
TL;DR: Exposure to whole-body low dose radiation significantly prevented type 2 diabetes-induced kidney injury characterized by renal dysfunction and pathological changes, and the protective mechanisms of LDR are complicated.
Antidiabetic effects of hesperidin and naringin in type 2 diabetic rats.
TL;DR: Results showed that hesperidin and naringin have potential antihyperglycemic and antidyslipidemic efficacies as well as cardiac function improving action in HFD/STZ-induced type 2 diabetic rats.
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Effects of antidiabetic drugs in high-fat diet and streptozotocin-nicotinamide-induced type 2 diabetic mice.
TL;DR: It is demonstrated that a high-fat diet combined with nicotinamide and streptozotocin injection induces a diabetic mouse model that replicates the metabolic characteristics of human type 2 diabetes.
References
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Journal ArticleDOI
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
TL;DR: How advances in the understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance is discussed.
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Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
TL;DR: Clinical studies in patients with type II diabetes, as well as other syndromes characterized by insulin resistance, have demonstrated that thiazolidinediones may represent a safe and effective new treatment.
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A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
M. J. Reed,K. Meszaros,L. J. Entes,M. D. Claypool,J. G. Pinkett,T.M Gadbois,Gerald M. Reaven +6 more
TL;DR: Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.