Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.About:
This article is published in Pharmacological Research.The article was published on 2005-10-01. It has received 1573 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
Citations
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Antidiabetic effects of water-soluble Korean pine nut protein on type 2 diabetic mice
Liu Didi,Joe M. Regenstein,Diao Yan,Junqiang Qiu,Hua Zhang,Li Jingtong,Haitian Zhao,Zhenyu Wang +7 more
TL;DR: Korean pine nut protein can regulate fasting blood glucose, improve insulin resistance, correct the glucose metabolism disorder in diabetic mice, and have a positive regulatory role.
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The nutraceutical potential of Lepidium sativum L. seed flavonoid-rich extract in managing metabolic syndrome components.
TL;DR: The dried LS extract showed an incredible set of effective flavonoids, which revealed hypoglycemic, hypolipidemic, anti-inflammatory, cytoprotective, and antidiabetic activities, which constitute a remarkable product to consider in pharmaceutical industry targeting diabetes and heart diseases.
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Diphenyleneiodonium Mitigates Bupivacaine-Induced Sciatic Nerve Damage in a Diabetic Neuropathy Rat Model by Attenuating Oxidative Stress.
Zhong-Hua Ji,Zhong-Jie Liu,Ziting Liu,Wei Zhao,Brian A. Williams,Hongfei Zhang,Le Li,Shiyuan Xu +7 more
TL;DR: Subcutaneous injection of DPI appears to protect against the functional and neurohistological damage of bupivacaine-blocked sciatic nerves in a high-fat diet/streptozotocin–induced DN model.
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Duodenal–Jejunal Bypass Improves Glucose Homeostasis in Association with Decreased Proinflammatory Response and Activation of JNK in the Liver and Adipose Tissue in a T2DM Rat Model
Chunxiao Hu,Qingbo Su,Feng Li,Guangyong Zhang,Dong Sun,Haifeng Han,Shaozhuang Liu,Sanyuan Hu +7 more
TL;DR: DJB achieved a rapid and sustainable glycemic control independently of weight loss and indicated that the improved proinflammatory state and decreased JNK activity after DJB may contribute to the improved glucose homeostasis.
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Fluorophore-Dapagliflozin Dyad for Detecting Diabetic Liver/Kidney Damages via Fluorescent Imaging and Treating Diabetes via Inhibiting SGLT2.
TL;DR: In this paper, a fluorophore-dapagliflozin dyad (DX-B-DA) was developed as a theranostic system that can be triggered by intrahepatic/intrarenal reactive oxygen species (ROS) to concomitantly release a near-infrared (NIR) fluorescent dye (DX) and a SGLT2 inhibitor dapaglialozin (DA).
References
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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
TL;DR: How advances in the understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance is discussed.
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Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
TL;DR: Clinical studies in patients with type II diabetes, as well as other syndromes characterized by insulin resistance, have demonstrated that thiazolidinediones may represent a safe and effective new treatment.
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A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
M. J. Reed,K. Meszaros,L. J. Entes,M. D. Claypool,J. G. Pinkett,T.M Gadbois,Gerald M. Reaven +6 more
TL;DR: Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.