Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.About:
This article is published in Pharmacological Research.The article was published on 2005-10-01. It has received 1573 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
Citations
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Antioxidant and Renoprotective Effects of Spirogyra neglecta (Hassall) Kützing Extract in Experimental Type 2 Diabetic Rats
Atcharaporn Ontawong,Naruwan Saowakon,Pornpun Vivithanaporn,Anchalee Pongchaidecha,Narissara Lailerd,Doungporn Amornlerdpison,Anusorn Lungkaphin,Chutima Srimaroeng +7 more
TL;DR: Findings indicate that SNE has beneficial effects on renal transport through antioxidant enzymes and PKCs in T2DM rats.
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Effects of combined inositol hexakisphosphate and inositol supplement on antioxidant activity and metabolic enzymes in the liver of streptozotocin-induced type 2 diabetic rats.
TL;DR: Combined IP6 and inositol treatment resulted in the preservation of liver cell integrity and improved antioxidant status in type 2 diabetic rats.
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Polyphenols-rich Cyamopsis tetragonoloba (L.) Taub. beans show hypoglycemic and β-cells protective effects in type 2 diabetic rats.
Gopalsamy Rajiv Gandhi,Pautu Vanlalhruaia,Antony Stalin,Santiagu Stephen Irudayaraj,Savarimuthu Ignacimuthu,Michael Gabriel Paulraj +5 more
TL;DR: Findings indicate that C. tetragonoloba beans have therapeutic potential in HFD fed-STZ-induced hyperglycemia; therefore this can be used in the management of type 2 diabetes.
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Cardioprotective and anti-hypertensive effects of Prosopis glandulosa in rat models of pre-diabetes
TL;DR: In this article, two-way ANOVA was used to compare the performance of different control and control groups in a two-group setting. But the results showed that p < 0.05 vs the respective control, and p > 0.001 vs the corresponding control.
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Trans‐11 vaccenic acid improves insulin secretion in models of type 2 diabetes in vivo and in vitro
Xiaofeng Wang,Joel Gupta,Matthew Kerslake,Gina R. Rayat,Spencer D. Proctor,Catherine B. Chan +5 more
TL;DR: Results indicate that VA may improve insulin secretion and growth of islets in T2D, at least partly by altering GPR40 and REG-1α mRNA expression.
References
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Journal ArticleDOI
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
TL;DR: How advances in the understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance is discussed.
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Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
TL;DR: Clinical studies in patients with type II diabetes, as well as other syndromes characterized by insulin resistance, have demonstrated that thiazolidinediones may represent a safe and effective new treatment.
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A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
M. J. Reed,K. Meszaros,L. J. Entes,M. D. Claypool,J. G. Pinkett,T.M Gadbois,Gerald M. Reaven +6 more
TL;DR: Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.