Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.About:
This article is published in Pharmacological Research.The article was published on 2005-10-01. It has received 1573 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
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Journal Article
Animal models in type 2 diabetes research: an overview.
K Srinivasan,P Ramarao +1 more
TL;DR: This review gives an overview on the animal models of type 2 diabetes with reference to their origin/source, characteristic features, underlying causes/mechanism, advantages and disadvantages to the investigators in diabetes research.
Journal ArticleDOI
The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model
TL;DR: Results indicated that high-fat diet combined with multiple low doses of STZ (30 mg/kg at weekly intervals for 2 weeks) proved to be a better way for developing a stable animal model of type 2 diabetes, and this new model may be suitable for pharmaceutical screening.
Journal ArticleDOI
Intracerebral streptozotocin model of type 3 diabetes: Relevance to sporadic Alzheimer's disease
Nataniel Lester-Coll,Enrique J. Rivera,Stephanie J. Soscia,Kathryn Doiron,Jack R. Wands,Suzanne M. de la Monte +5 more
TL;DR: The results demonstrate that many of the characteristic features of AD-type neurodegeneration can be produced experimentally by selectively impairing insulin/IGF functions together with increasing oxidative stress, and support the hypothesis that AD represents a neuro-endocrine disorder associated with brain-specific perturbations in insulin and IGF signaling mechanisms, i.e. Type 3 diabetes.
Journal ArticleDOI
Modeling type 2 diabetes in rats using high fat diet and streptozotocin
TL;DR: The present review summarizes the current understanding of the metabolic profile and pathology involved in the different stages of the type 2 diabetes disease progression in humans and examines the suitability of the high‐fat diet‐fed, streptozotocin (HFD/STZ)‐treated rat model as a model of type 1 diabetes.
Journal ArticleDOI
MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus
Dwi Setyowati Karolina,Arunmozhiarasi Armugam,Subramaniam Tavintharan,Michael T. K. Wong,Su Chi Lim,Chee Fang Sum,Kandiah Jeyaseelan,Kandiah Jeyaseelan +7 more
TL;DR: It is demonstrated that peripheral blood microRNAs can be developed as unique biomarkers that are reflective and predictive of metabolic health and disorder.
References
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Journal ArticleDOI
Inducement by fat feeding of basal hyperglycemia in rats with abnormal beta-cell function. Model for study of etiology and pathogenesis of NIDDM.
TL;DR: The interaction between diet, insulin secretion and action, and the autonomic nervous system in the development of hyperglycemia is highlighted, and addition of dietary fatinduced insulin resistance resulted in basal hyper glycemia and marked deterioration of glucose tolerance.
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Effect of pioglitazone on insulin receptors of skeletal muscles from high-fat-fed rats
TL;DR: The results suggest that pioglitazone increases insulin sensitivity by activating tyrosine kinase activity of receptors in high-fat-fed rats, and this drug appears to be a useful one with a new mode of action for the treatment of NIDDM with insulin resistance.
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Pioglitazone hydrochloride inhibits cholesterol absorption and lowers plasma cholesterol concentrations in cholesterol-fed rats
Jerry R. Colca,Charlene F Dailey,Barbara J. Palazuk,Roberta M Hillman,Dac M. Dinh,George W Melchior,Charles H. Spilman +6 more
TL;DR: Treatment of rats with pioglitazone hydrochloride, a novel antidiabetic compound that improves the general response of target cells to insulin, significantly lowered cholesterol levels in rats fed a hypercholesterolemic diet and produced a significant reduction in cholesterol absorption.
Journal ArticleDOI
Low-dose streptozotocin-induced diabetes in the spontaneously hypertensive rat
TL;DR: Results indicate that SHR were more sensitive to the effects of a decrease in pancreatic beta-cell function (STZ) and an increase in insulin resistance (fructose feeding) than WKY rats.
Journal Article
Insulin resistance: current therapeutic approaches.
P Ramarao,C L Kaul +1 more
TL;DR: Elucidation of the mechanism(s) of these agents may provide new targets for which selective ligands with better efficacy and low toxicity can be found.