Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.About:
This article is published in Pharmacological Research.The article was published on 2005-10-01. It has received 1573 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
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QCM-4, a 5-HT₃ receptor antagonist ameliorates plasma HPA axis hyperactivity, leptin resistance and brain oxidative stress in depression and anxiety-like behavior in obese mice.
TL;DR: QCM-4 showed antidepressive and anxiolytic effect by reversing the behavioral alterations that were supported by biochemical estimations in obese mice.
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Deferoxamine-activated hypoxia-inducible factor-1 restores cardioprotective effects of sevoflurane postconditioning in diabetic rats.
Peng Xie,L. Yang,A. Talaiti,Jianjiang Wu,Jin Yu,T. Yu,H. Y. Wang,B. Huang,Q. Wu,Yiliyaer Maimaitili,Jiang Wang,Haiping Ma,Yining Yang,Hong Zheng +13 more
TL;DR: This study investigated whether deferoxamine (DFO)‐induced activation of HIF‐1 signalling pathway can restore the cardioprotective effects of SpostC in diabetic rats.
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High fat diet feeding induced insulin resistance exacerbates 6-OHDA mediated neurotoxicity and behavioral abnormalities in rats.
Sorabh Sharma,Rajeev Taliyan +1 more
TL;DR: Interestingly, it was found that exposure to HFD exacerbated the effects of 6‐OHDA on striatal dopamine loss and behavioral parameters in rats, indicating that HFD‐induced insulin resistance is associated with a diminished capacity of dopaminergic neurons to cope with 6‐ OHDA mediated neurotoxicity.
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Antidiabetic Effect of Sargassum wightii and Ulva fasciata in High fat diet and Multi Low Dose Streptozotocin Induced Type 2 Diabetic Mice
TL;DR: The findings suggest that these seaweeds offer a great opportunity to satisfy the food and nutrition requirement for rectifying and controlling diabetes.
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Vitamin K2 alleviates type 2 diabetes in rats by induction of osteocalcin gene expression.
TL;DR: Vit K2 administration could improve glycemic status in type 2 diabetic rats by induction of OC gene expression and Osteocalcin could increase β-cell proliferation, energy expenditure, and adiponectin expression.
References
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Journal ArticleDOI
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
TL;DR: How advances in the understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance is discussed.
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Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
TL;DR: Clinical studies in patients with type II diabetes, as well as other syndromes characterized by insulin resistance, have demonstrated that thiazolidinediones may represent a safe and effective new treatment.
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A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
M. J. Reed,K. Meszaros,L. J. Entes,M. D. Claypool,J. G. Pinkett,T.M Gadbois,Gerald M. Reaven +6 more
TL;DR: Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.