Journal ArticleDOI
Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening.
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TLDR
The present study represents that the combination of HFD-fed and low-dose STZ-treated rat serves as an alternative animal model for type 2 diabetes simulating the human syndrome that is also suitable for testing anti-diabetic agents for the treatment of type 1 diabetes.About:
This article is published in Pharmacological Research.The article was published on 2005-10-01. It has received 1573 citations till now. The article focuses on the topics: Insulin resistance & Glucose tolerance test.read more
Citations
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Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the therapeutic impact of calpain inhibitor.
Ahmed Y. Shanab,Toru Nakazawa,Morin Ryu,Yuji Tanaka,Noriko Himori,Keiko Taguchi,Masayuki Yasuda,Ryo Watanabe,Jiro Takano,Takaomi C. Saido,Naoko Minegishi,Toshio Miyata,Toshiaki Abe,Masayuki Yamamoto +13 more
TL;DR: The results suggest that calpain plays a crucial role in metabolic-induced RGC degeneration caused by hyperglycemia and oxidative stress and offers important opportunities for future neuroprotective treatment against RGC death in various metabolic stress-induced diseases including DR.
Journal ArticleDOI
Effects of angiotensin II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic rats
Ri-Ning Tang,Lin-Li Lv,Jiandong Zhang,Hou-Yong Dai,Qing Li,Min Zheng,Jie Ni,Kun-Ling Ma,Bi-Cheng Liu +8 more
TL;DR: The results provide the novel insight that an angiotensin II receptor blocker might prevent diabetic cardiomyopathy by abrogating EndMT in diabetic rats.
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Anti-diabetic activities of Gegen Qinlian Decoction in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes.
Chang-Hua Zhang,Guoliang Xu,YuHui Liu,Yi Rao,Riyue Yu,Zhong-Wei Zhang,Yue-Sheng Wang,Yue-Sheng Wang,Liang Tao +8 more
TL;DR: The present study investigated the anti-diabetic effects of GGQLD in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes and validated the beneficial effects of Gegen Qinlian Decoction as an anti-Diabetic agent.
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The Protective Effect of Astaxanthin on Cognitive Function via Inhibition of Oxidative Stress and Inflammation in the Brains of Chronic T2DM Rats.
TL;DR: Astaxanthin might inhibit oxidative stress and inflammatory responses by activating the Nrf2-ARE signaling pathway, which implies that AST ameliorated the impairment in the neurons of diabetic rats.
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Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia
James T. Thackeray,Jerry Radziuk,Mary-Ellen Harper,Erik J. Suuronen,Kathryn J. Ascah,Rob S. Beanlands,Jean N. DaSilva +6 more
TL;DR: Sustained hyperglycemia is associated with elevated myocardial NE content and dysregulation of sympathetic nervous system signaling in the absence of systolic impairment, suggesting diastolic impairment of the left ventricle.
References
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Journal ArticleDOI
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
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PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.
TL;DR: How advances in the understanding of nuclear receptor function, particularly the docking of cofactors in a ligand-dependent fashion, should lead to improved drugs that utilize the PPAR-gamma system for the treatment of insulin resistance is discussed.
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Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
TL;DR: Clinical studies in patients with type II diabetes, as well as other syndromes characterized by insulin resistance, have demonstrated that thiazolidinediones may represent a safe and effective new treatment.
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A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.
M. J. Reed,K. Meszaros,L. J. Entes,M. D. Claypool,J. G. Pinkett,T.M Gadbois,Gerald M. Reaven +6 more
TL;DR: Fat-fed/STZ rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.