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Journal ArticleDOI

Conn: A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks

TLDR
The results indicate that the CompCor method increases the sensitivity and selectivity of fcMRI analysis, and show a high degree of interscan reliability for many fc MRI measures.
Abstract
Resting state functional connectivity reveals intrinsic, spontaneous networks that elucidate the functional architecture of the human brain. However, valid statistical analysis used to identify such networks must address sources of noise in order to avoid possible confounds such as spurious correlations based on non-neuronal sources. We have developed a functional connectivity toolbox Conn (www.nitrc.org/projects/conn) that implements the component-based noise correction method (CompCor) strategy for physiological and other noise source reduction, additional removal of movement, and temporal covariates, temporal filtering and windowing of the residual blood oxygen level-dependent (BOLD) contrast signal, first-level estimation of multiple standard functional connectivity magnetic resonance imaging (fcMRI) measures, and second-level random-effect analysis for resting state as well as task-related data. Compared to methods that rely on global signal regression, the CompCor noise reduction method all...

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Citations
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Integration and Segregation of Default Mode Network Resting-State Functional Connectivity in Transition-Age Males with High-Functioning Autism Spectrum Disorder: A Proof-of-Concept Study

TL;DR: In this paper, Resting-state functional connectivity (RsFc) profile of the default mode network (DMN) in transition-age males with autism spectrum disorder (ASD) was assessed by assessing the positive and negative correlations of an average of the literature-based conceptualized major DMN nodes.
Journal ArticleDOI

Functional Connectivity Anomalies in Adolescents with Psychotic Symptoms

TL;DR: It is suggested that young adolescents with subclinical psychotic symptoms exhibit functional connectivity anomalies directly and indirectly involving the DMN, SN, CEN and also a neural network including both primary and secondary auditory cortical regions.
Journal ArticleDOI

The role of anxiety in stuttering: Evidence from functional connectivity.

TL;DR: This is the first study to examine the neural underpinnings of anxiety in PWS, thus yielding new insight into the causes of stuttering which might aid strategies for the diagnosis and treatment of stuttered.
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Altered frontal and insular functional connectivity as pivotal mechanisms for apathy in Alzheimer's disease.

TL;DR: The findings support a role of frontal and insular connections in coordinating value-based decisions in AD and both down-regulation and maladaptive up-regulation mechanisms appear to be at play in these regions.
References
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Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.

TL;DR: It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.
Journal ArticleDOI

The Brain's Default Network Anatomy, Function, and Relevance to Disease

TL;DR: Past observations are synthesized to provide strong evidence that the default network is a specific, anatomically defined brain system preferentially active when individuals are not focused on the external environment, and for understanding mental disorders including autism, schizophrenia, and Alzheimer's disease.
Related Papers (5)
Trending Questions (1)
What are the uses of CONN toolbox in ICA analysis when studying clinical populations?

The paper does not specifically mention the use of the CONN toolbox in ICA analysis when studying clinical populations.